934975-03-8Relevant academic research and scientific papers
1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation
Wei, Robert G.,Adler, Marc,Davey, David,Ho, Elena,Mohan, Raju,Polokoff, Mark,Tseng, Jih-Lie,Whitlow, Marc,Xu, Wei,Yuan, Shendong,Phillips, Gary
, p. 2499 - 2504 (2008/02/04)
A new series of 1-(1,3-benzodioxol-5-ylmethyl)-3-[4-(1H-Imidazol-1-yl)phenoxy]-piperidine analogs were designed and identified as potent and selective inhibitors of NO formation based both on the crystal structure of a murine iNOS Δ114 monomer domain/ inhibitor complex and inhibition of the NO formation in human A172 cell assays. Compound 12S showed high potency and high iNOS selectivity versus nNOS and eNOS.
