934995-82-1

Basic information

• Product Name: C₁₂H₁₂BrFO₂
• Synonyms: C₁₂H₁₂BrFO₂
• CAS NO: 934995-82-1
• Molecular Weight: 287.128
• Mol File: 934995-82-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₂BrFO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₂BrFO₂(934995-82-1)
• EPA Substance Registry System: C₁₂H₁₂BrFO₂(934995-82-1)

Safety Data

• Hazardous Substances Data: 934995-82-1(Hazardous Substances Data)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 627463-17-6 4-bromo-2-fluoro-1-vinylbenzene 
• 934995-83-2 C₁₀H₈BrFO₂ 
• 64-17-5 ethanol 

Downstream Products

• 934995-86-5 C₃₀H₂₆FN₃O₄ 
• 934995-83-2 C₁₀H₈BrFO₂ 

Relevant articles and documents

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

The structure-activity relationship of a novel series of 8-biarylnaphthyridinones acting as type 4 phosphodiesterase (PDE4) inhibitors for the treatment of long-term memory loss and mild cognitive impairment is described herein. The manuscript describes a new paradigm for the development of PDE4 inhibitor targeting CNS indications. This effort led to the discovery of the clinical candidate MK-0952, an intrinsically potent inhibitor (IC 50 = 0.6 nM) displaying limited whole blood activity (IC50 = 555 nM). Supporting in vivo results in two preclinical efficacy tests and one test assessing adverse effects are also reported. The comparative profiles of MK-0952 and two other Merck compounds are described to validate the proposed hypothesis.

4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitor and a method of preparing same

The invention is directed to a compound of the structural formula (22) crystal form of structural formulae (21) and its free acid, pharmaceutical compositions comprising these compounds and methods of preparing and using these compounds.