935-34-2Relevant academic research and scientific papers
Oxidation-initiated nazarov cyclization of vinyl alkoxyallenes
Spencer III, William T.,Levin, Mark D.,Frontier, Alison J.
supporting information; experimental part, p. 414 - 417 (2011/04/15)
A mild method for the diastereoselective formation of C4, C 5-disubstituted cyclopentenones has been developed, involving formation of a pentadienyl cation via diastereoselective oxidation of a vinyl alkoxyallene. Conrotatory electrocyclization provides the cyclopentenone product. The broad scope, mild conditions, and uncommon substitution pattern accessible through this transformation make it a useful addition to the existing repertoire of cyclopentenone synthetic methods.
