93512-67-5Relevant academic research and scientific papers
Synthesis of indoles: Tetrahydropyrazino[1,2-a]indole-1,4-dione and pyrazino[1,2-a]indole-6,13-diones from piperazine-2,5-diones
Akeng'a,Read
, p. 93 - 97 (2007/10/03)
The readily available piperazine-2,5-dione has been used to prepare both 1:1 (1-3), with stereotopic methylene protons; and 2:1 (4-6) arylmethylenepiperazine-2,5-diones in above average yields. The halo-derivatives, 1, 4 and 5 were cyclized to pyrazino[1,2-a]indoles, 7-9, using copper bronze. Indole compounds 7 and 9 were further treated, separately, with lithium aluminium hydride, sodium borohydride, lithium hydroxide monohydrate and butyl lithium to yield 2-substituted indoles 10-13.
Pyrazine Chemistry. II. Reduction of 3,6-Dibenzylidenepiperazine-2,5-diones
Marcuccio, Sebastian M.,Elix, John A.
, p. 1791 - 1794 (2007/10/02)
A reinvestigation of the reduction of 3,6-dibenzylidenepiperazine-2,5-dione (1) with zinc and acetic acid established that this reaction gave (Z)-6-benzyl-3-benzylidenepiperazine-2,5-dione (10).When a mixture of acetic acid and hydrochloric acid was used
