93517-76-1

Basic information

• Product Name: 4-(2,5-DIMETHYL-PHENYL)-2H-PHTHALAZIN-1-ONE
• Synonyms: 4-(2,5-Dimethyl-phenyl)-2H-phthalazin-1-one
• CAS NO: 93517-76-1
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.3
• Mol File: 93517-76-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.19g/cm³
• Refractive Index: 1.636
• CAS DataBase Reference: 4-(2,5-DIMETHYL-PHENYL)-2H-PHTHALAZIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,5-DIMETHYL-PHENYL)-2H-PHTHALAZIN-1-ONE(93517-76-1)
• EPA Substance Registry System: 4-(2,5-DIMETHYL-PHENYL)-2H-PHTHALAZIN-1-ONE(93517-76-1)

Safety Data

• Hazardous Substances Data: 93517-76-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H14N2O/c1-10-7-8-11(2)14(9-10)15-12-5-3-4-6-13(12)16(19)18-17-15/h3-9H,1-2H3,(H,18,19)

Upstream product

• 106-42-3 para-xylene 
• 1875-48-5 N-aminophthalamide 
• 129934-46-9 3-(2,5-Dimethyl-phenyl)-3-hydroxy-2-phenyl-2,3-dihydro-isoindol-1-one 
• 60288-22-4 1,4-dimethyl-2-(o-carboxybenzoyl)benzene 

Relevant articles and documents

TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF

Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.

NEW CONVENIENT ONE-STEP SYNTHESIS OF 4-ARYLPHTHALAZ-1-ONES

4-Arylphthalaz-1-ones (2a-e) are prepared by the hitherto unknown reaction of N-aminophthalimide (1) with aromatic hydrocarbons under Friedel-Crafts conditions.The reaction of N-aminophthalimide with Grignard reagents presents another convenient method for the synthesis of 4-alkyl or 4-arylphthalaz-1-ones.