60288-22-4

Basic information

• Product Name: 2-(2,5-DIMETHYL-BENZOYL)-BENZOIC ACID
• Synonyms: 2-[(2,5-dimethylphenyl)-oxomethyl]benzoic acid;2'-Carboxy-2,5-dimethylbenzophenone
• CAS NO: 60288-22-4
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.29
• Mol File: 60288-22-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 442.9°C at 760 mmHg
• Flash Point: 235.8°C
• Appearance: /
• Density: 1.195g/cm³
• Vapor Pressure: 1.27E-08mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 2-(2,5-DIMETHYL-BENZOYL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,5-DIMETHYL-BENZOYL)-BENZOIC ACID(60288-22-4)
• EPA Substance Registry System: 2-(2,5-DIMETHYL-BENZOYL)-BENZOIC ACID(60288-22-4)

Safety Data

• Hazardous Substances Data: 60288-22-4(Hazardous Substances Data)

Usage

General Description

2-(2,5-DIMETHYL-BENZOYL)-BENZOIC ACID is a chemical compound that belongs to the class of benzoic acid derivatives. It is commonly used in the synthesis of pharmaceuticals, particularly in the development of anti-inflammatory drugs and other medications. 2-(2,5-DIMETHYL-BENZOYL)-BENZOIC ACID serves as a building block in the production of various organic molecules due to its versatile reactivity and functional groups. Its molecular structure includes a benzene ring with two substituents, one of which is a benzoic acid group, and the other is a 2,5-dimethylbenzoyl group. This chemical has potential applications in the fields of medicine, agrochemicals, and materials science.

InChI:InChI=1/C16H14O3/c1-10-7-8-11(2)14(9-10)15(17)12-5-3-4-6-13(12)16(18)19/h3-9H,1-2H3,(H,18,19)

Upstream product

• 85-44-9 phthalic anhydride 
• 106-42-3 para-xylene 
• 88-95-9 Phthaloyl dichloride 
• 7446-70-0 aluminium trichloride 

Downstream Products

• 2224-85-3 4-(2,5-dimethyl-phenyl)-benzo[d][1,2]oxazin-1-one 
• 5218-20-2 9b-(2,5-dimethyl-phenyl)-2,3-dihydro-9bH-[1,3]thiazolo[2,3-a]isoindol-5-one 
• 101110-15-0 3-(2,5-dimethylphenyl)isobenzofuran-1(3H)-one 
• 65-85-0 benzoic acid 
• 610-72-0 2,5-dimethylbenzoic acid 
• 329922-53-4 4-(2,5-dimethylphenyl)-2-(2-nitro-5-chlorophenyl)-1,2-dihydrophthalazin-1(2H)-one 
• 1252-11-5 1-(2-Carboxy-benzyl)-4-(2-carboxybenzoyl)-2,5-dimethylbenzol 
• 860602-78-4 1,2-bis-(2,5-dimethyl-benzoyl)-benzene 
• 613-12-7 2-methylanthracene 
• 847468-11-5 4-(2,5-dimethylphenyl)-2-(2-nitro-5-piperidinophenyl)-1,2-dihydro-1-phthalazinone 
• 1148-60-3 2-(2,5-dimethyl-benzyl)-benzoic acid 
• 93517-76-1 4-(2,5-dimethyl-phenyl)-2H-phthalazin-1-one 

Relevant articles and documents

Mechanochemical Friedel-crafts acylations

Friedel-Crafts (FC) acylation reactions were exploited in the preparation of ketone-functionalized aromatics. Environmentally more friendly, solvent-free mechanochemical reaction conditions of this industrially important reaction were developed. Reaction parameters such as FC catalyst, time, ratio of reagents and milling support were studied to establish the optimal reaction conditions. The scope of the reaction was explored by employment of different aromatic hydrocarbons in conjunction with anhydrides and acylation reagents. It was shown that certain FC-reactive aromatics could be effectively functionalized by FC acylations carried out under ball-milling conditions without the presence of a solvent. The reaction mechanism was studied by in situ Raman and ex situ IR spectroscopy.

1,4-disubstituted anthracene antitumor agents

Three different types of 1,4-disubstituted anthracenes were synthesized, and their cytotoxicity in a panel of tumor cells was compared with that of the corresponding 9,10-disubstituted anthracenes. The panel contained human myeloma, melanoma, colon, and lung cancer cells and sensitive and multidrug- resistant murine L1210 leukemia cells. These compounds had [[(dimethylamino)ethyl]amino]methyl, N-[(dimethylamino)ethyl]carbamoyl, and carboxaldehyde (4,5-dihydro-1H-imidazol-2-yl)hydrazone side chains. The 1,4- diamide was more potent across the tumor panel than the corresponding 9,10- isomer, but the 1,4-diamine and the 1,4-hydrazone were less potent than their 9,10-isomers. Although the 1,4-hydrazone was active against P388 leukemia in mice, it was inactive against L1210 leukemia. Within each pair of compounds, the one with greater average potency against tumor cells gave a greater increase in the transition melt temperature of DNA.