60288-22-4

Usage

Uses

Used in Pharmaceutical Industry:
2-(2,5-DIMETHYL-BENZOYL)-BENZOIC ACID is used as a key intermediate in the synthesis of anti-inflammatory drugs and other medications, contributing to the development of new pharmaceuticals that address various health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(2,5-DIMETHYL-BENZOYL)-BENZOIC ACID is utilized as a component in the creation of various agrochemical products, potentially enhancing crop protection and yield.
Used in Materials Science:
2-(2,5-DIMETHYL-BENZOYL)-BENZOIC ACID also finds applications in materials science, where it can be employed to develop new materials with specific properties, such as improved stability or reactivity, for use in various industrial applications.

InChI:InChI=1/C16H14O3/c1-10-7-8-11(2)14(9-10)15(17)12-5-3-4-6-13(12)16(18)19/h3-9H,1-2H3,(H,18,19)

Upstream product

• 85-44-9 phthalic anhydride 
• 106-42-3 para-xylene 
• 88-95-9 Phthaloyl dichloride 
• 7446-70-0 aluminium trichloride 

Downstream Products

• 101110-15-0 3-(2,5-dimethylphenyl)isobenzofuran-1(3H)-one 
• 93517-76-1 4-(2,5-dimethyl-phenyl)-2H-phthalazin-1-one 
• 1148-60-3 2-(2,5-dimethyl-benzyl)-benzoic acid 
• 65-85-0 benzoic acid 
• 610-72-0 2,5-dimethylbenzoic acid 
• 1252-11-5 1-(2-Carboxy-benzyl)-4-(2-carboxybenzoyl)-2,5-dimethylbenzol 
• 860602-78-4 1,2-bis-(2,5-dimethyl-benzoyl)-benzene 
• 613-12-7 2-methylanthracene 
• 847468-11-5 4-(2,5-dimethylphenyl)-2-(2-nitro-5-piperidinophenyl)-1,2-dihydro-1-phthalazinone 
• 329922-53-4 4-(2,5-dimethylphenyl)-2-(2-nitro-5-chlorophenyl)-1,2-dihydrophthalazin-1(2H)-one 
• 5218-20-2 9b-(2,5-dimethyl-phenyl)-2,3-dihydro-9bH-[1,3]thiazolo[2,3-a]isoindol-5-one 
• 2224-85-3 4-(2,5-dimethyl-phenyl)-benzo[d][1,2]oxazin-1-one 

Relevant academic research and scientific papers

Mechanochemical Friedel-crafts acylations

Friedel-Crafts (FC) acylation reactions were exploited in the preparation of ketone-functionalized aromatics. Environmentally more friendly, solvent-free mechanochemical reaction conditions of this industrially important reaction were developed. Reaction parameters such as FC catalyst, time, ratio of reagents and milling support were studied to establish the optimal reaction conditions. The scope of the reaction was explored by employment of different aromatic hydrocarbons in conjunction with anhydrides and acylation reagents. It was shown that certain FC-reactive aromatics could be effectively functionalized by FC acylations carried out under ball-milling conditions without the presence of a solvent. The reaction mechanism was studied by in situ Raman and ex situ IR spectroscopy.

An alternative route to syntheses of aryl keto acids in a chloroaluminate ionic liquid

The Lewis acidic 1-butyl-3-methylimidazolium chloroaluminate ionic liquid [bmim]Cl.AlCl3, N=0.67, is employed as a catalyst as well as the solvent for the quick and efficient syntheses of aryl keto acids by Friedel-Crafts acylation and aroylation of aromatic hydrocarbons using cyclic acid anhydrides.

1,4-disubstituted anthracene antitumor agents

Three different types of 1,4-disubstituted anthracenes were synthesized, and their cytotoxicity in a panel of tumor cells was compared with that of the corresponding 9,10-disubstituted anthracenes. The panel contained human myeloma, melanoma, colon, and lung cancer cells and sensitive and multidrug- resistant murine L1210 leukemia cells. These compounds had [[(dimethylamino)ethyl]amino]methyl, N-[(dimethylamino)ethyl]carbamoyl, and carboxaldehyde (4,5-dihydro-1H-imidazol-2-yl)hydrazone side chains. The 1,4- diamide was more potent across the tumor panel than the corresponding 9,10- isomer, but the 1,4-diamine and the 1,4-hydrazone were less potent than their 9,10-isomers. Although the 1,4-hydrazone was active against P388 leukemia in mice, it was inactive against L1210 leukemia. Within each pair of compounds, the one with greater average potency against tumor cells gave a greater increase in the transition melt temperature of DNA.