935248-44-5Relevant academic research and scientific papers
Synthesis of the C1 – C16 fragment of bryostatin for incorporation into 20,20-fluorinated analogues
Mears, Paul R.,Thomas, Eric J.
, (2020/12/07)
The stereoselective synthesis of a carboxylic acid ester corresponding to the C1–C16 fragment of bryostatin, with 4-methoxybenzyl (PMB) protection for the 7-hydroxyl group, is reported. The key steps included a Horner-Wadsworth-Emmons reaction between (5R
Total syntheses of bryostatins: Synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment
Trost, Barry M.,Yang, Hanbiao,Dong, Guangbin
, p. 9789 - 9805 (2011/10/08)
Herein, we report the synthesis of novel ring-expanded bryostatin analogues. By carefully modifying the substrate, a selective and high-yielding Ru-catalyzed tandem enyne coupling/Michael addition was employed to construct the northern fragment. Ring-clos
Synthesis of the C9-C23 (C9′-C23′) fragment of the dimeric natural product rhizopodin
Chen, Zheng,Song, Liankai,Xu, Zhengshuang,Ye, Tao
supporting information; experimental part, p. 2036 - 2039 (2010/07/03)
Figure presented A stereoselective assembly of the C9-C23 (C9′-C23′) fragment of rhizopodin, a 38-membered bis-lactone natural product, has been developed. A highly efficient approach to this fragment assembles >50% of the carbon skeleton and the stereoch
Synthesis of a ring-expanded bryostatin analogue
Trost, Barry M.,Yang, Hanbiao,Thiel, Oliver R.,Frontier, Alison J.,Brindle, Cheyenne S.
, p. 2206 - 2207 (2008/02/01)
A ring-expanded bryostatin analogue was synthesized by utilizing a Ru-catalyzed tandem tetrahydropyran formation, a Pd-catalyzed tandem dihydropyran formation, and a ring-closing metathesis (RCM) as key steps. The analogue possesses potent antitumor activ
