935263-25-5

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Downstream Products

• 1133831-74-9 (R(S))-N-((R,E)-1-(4-(trifluoromethyl)phenyl)hex-2-enyl)-2-methylpropanesulfinamide 
• 1636179-17-3 (R)-N-((S)-(9-isocyano-9H-fluoren-9-yl)(4-(trifluoromethyl)phenyl)methyl)-2-methylpropane-2-sulfinamide 
• 1448897-91-3 C₂₄H₃₀F₆N₂O₂S₂ 
• 1443323-78-1 (2R,3R)-1-((R)-tert-butylsulfinyl)-2-(4-(trifluoromethyl)phenyl)-3-vinylaziridine 
• 1256350-34-1 C₁₃H₁₂F₃NO 
• 1015198-64-7 C₁₅H₂₀F₃NOS 

Relevant academic research and scientific papers

Stereoselective synthesis of -sulfinylamino isocyanides and 2-imidazolines

An efficient asymmetric synthesis of -sulfinylamino isocyanides is reported on the basis of the highly diastereoselective addition of 9-isocyanofluorene to optically pure N-tert-butanesulfinimines. The resulting optically pure isocyanides readily cyclized to give optically pure 2-imidazolines upon removal of the sulfinyl group. Furthermore, the -sulfinylamino isocyanides were used as chiral inputs in Ugi and Passerini multicomponent reactions to generate new types of (pseudo)peptide scaffolds. Optically pure -sulfinylamino isocyanides are synthesized in a highly diastereoselective addition of 9-isocyanofluorene with N-tert-butanesulfinimines. Follow-up chemistry demonstrates that they are excellent precursors for the preparation of optically pure 2-imidazolines. Furthermore, they are applied in Ugi and Passerini multicomponent reactions; TMSOTf = trimethylsilyl trifluoromethanesulfonate, DIPEA = N,N- diisopropylethylamine. Copyright

Synthesis and in vitro antitumor activity of novel iridium(III) complexes with enantiopure C2-symmetrical vicinal diamine ligands

Four novel iridium(III) complexes with enantiopure C2- symmetrical vicinal diamine ligands were designed, synthesized, and characterized by FT-IR, NMR, and MS. The cytotoxicities of all of the complexes against the human solid tumor cell lines

TRP-M8 RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS

Tetrahydroisoquinoline compounds of formula (I), and compositions containing them, for the treatment of acute, inflammatory and neurophatic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neurophatic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintened pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.