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1-{5-iodo-3-methyl-2-[1-pyrrolidinyldiazenyl]phenyl}ethanone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

935292-75-4

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935292-75-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 935292-75-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,5,2,9 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 935292-75:
(8*9)+(7*3)+(6*5)+(5*2)+(4*9)+(3*2)+(2*7)+(1*5)=194
194 % 10 = 4
So 935292-75-4 is a valid CAS Registry Number.

935292-75-4Relevant academic research and scientific papers

Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitors

Lunniss,Eldred,Aston,Craven,Gohil,Judkins,Keeling,Ranshaw,Robinson,Shipley,Trivedi

scheme or table, p. 137 - 140 (2010/04/26)

Species specific conversion of the lead PDE4 inhibitor 1 to the quinolone 3 was identified as the major route of metabolism in the cynomolgus monkey. Modification of the template to give the cinnoline 9 retained potency and selectivity, and greatly improved the pharmacokinetic profile in the cynomolgus monkey compared with 1. Additional SAR studies aimed at improving the solubility of 9 are also described.

CINNOLINE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE TYPE IV (PDE4)

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Page/Page column 70-71, (2010/11/27)

There are provided according to the invention novel compounds of formula (I).

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