93530-73-5Relevant academic research and scientific papers
Stereospecific Synthesis of 2-Deuterio-3-hydroxybutanoate Esters. Regiochemistry and Stereochemistry of Homogenous Hydrogenation with Wilkinson's Catalyst
Mohrig, Jerry R.,Dabora, Sandra L.,Foster, Ted F.,Schultz, Steve C.
, p. 5179 - 5182 (2007/10/02)
Hydrogenation of the methyl esters of (Z)- and (E)-3-(benzoyloxy)-2-butenoate produces reduced products in good yield with highly stereoselective syn additon.Reaction of the alkenes with deuterium is preferable to reaction of the 2-deuterioalkenes with hydrogen.NMR measurements indicated 99.8 percent or greater syn addition of D2 with the Z alkene.Addition of HD to the E alkene produced no regioselectivity, indicating that either the alkylrhodium intermediate forms without kinetic isotope effects or without regioselectivity.
