935445-78-6

Basic information

• Product Name: 6-({2-[(4-tolyl)amino]-2-oxoethyl}thio)-5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}nicotinamide
• CAS NO: 935445-78-6
• Molecular Weight: 679.78
• Mol File: 935445-78-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-({2-[(4-tolyl)amino]-2-oxoethyl}thio)-5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}nicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-({2-[(4-tolyl)amino]-2-oxoethyl}thio)-5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}nicotinamide(935445-78-6)
• EPA Substance Registry System: 6-({2-[(4-tolyl)amino]-2-oxoethyl}thio)-5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}nicotinamide(935445-78-6)

Safety Data

• Hazardous Substances Data: 935445-78-6(Hazardous Substances Data)

Upstream product

• 134477-88-6 3-oxo-N-{4-[(pyrimidin-2-ylamino)sulphonyl]phenyl}butanamide 
• 935445-52-6 5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-6-thioxo-1,6-dihydropyridine-3-carboxamide 
• 16634-82-5 N-(p-tolyl)-2-chloroacetamide 
• 68-35-9 sulfadiazine 

Downstream Products

• 935445-86-6 3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide 

Relevant articles and documents

Acetoacetanilides in heterocyclic synthesis, Part 1: An expeditious synthesis of thienopyridines and other fused derivatives

3-Oxo-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}butanamide 1 reacts with arylidinecyanothioacetamide in refluxing ethanolic TEA to give the pyridinethione 2 rather than thiopyrane 4. Compound 2 reacts with α-haloketones to give the s-alkylated derivative