935445-52-6

Basic information

• Product Name: 5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-6-thioxo-1,6-dihydropyridine-3-carboxamide
• CAS NO: 935445-52-6
• Molecular Weight: 532.604
• Mol File: 935445-52-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-6-thioxo-1,6-dihydropyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-6-thioxo-1,6-dihydropyridine-3-carboxamide(935445-52-6)
• EPA Substance Registry System: 5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-6-thioxo-1,6-dihydropyridine-3-carboxamide(935445-52-6)

Safety Data

• Hazardous Substances Data: 935445-52-6(Hazardous Substances Data)

Upstream product

• 68-35-9 sulfadiazine 
• 68029-57-2 2-cyano-3-(4-methoxyphenyl)thioacrylamide 
• 134477-88-6 3-oxo-N-{4-[(pyrimidin-2-ylamino)sulphonyl]phenyl}butanamide 

Downstream Products

• 935445-90-2 3-(acetylamino)-4-(4-methoxyphenyl)-6-methyl-N⁵-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-N²-(4-chlorophenyl)thieno[2,3-b]pyridine-2,5-dicarboxamide 
• 935445-89-9 3-(acetylamino)-4-(4-methoxyphenyl)-6-methyl-N⁵-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-N²-(4-tolyl)thieno[2,3-b]pyridine-2,5-dicarboxamide 
• 935445-85-5 3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 2-[(4-chloro-phenyl)-amide] 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 
• 935445-86-6 3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide 
• 935445-88-8 3-(acetylamino)-4-(4-methoxyphenyl)-6-methyl-N⁵-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-N²-phenylthieno[2,3-b]pyridine-2,5-dicarboxamide 
• 935445-82-2 ethyl 3-amino-4-(4-methoxyphenyl)-6-methyl-5-[({4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}amino)carbonyl]thieno[2,3-b]pyridine-2-carboxylate 
• 935445-56-0 9-(4-methoxyphenyl)-2,7-dimethyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d][1,3]oxazine-8-carboxamide 
• 935445-87-7 3-amino-4-(4-methoxyphenyl)-6-methyl-5-[({4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}amino)carbonyl]thieno[2,3-b]pyridine-2-carboxamide 
• 935445-62-8 9-(4-methoxyphenyl)-7-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxamide 
• 935445-72-0 {3-cyano-4-(4-methoxy-phenyl)-6-methyl-5-[4-(pyrimidin-2-ylsulfamoyl)-phenylcarbamoyl]-pyridin-2-ylsulfanyl}-acetic acid ethyl ester 
• 935445-80-0 6-carbamoylmethylsulfanyl-5-cyano-4-(4-methoxy-phenyl)-2-methyl-N-[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-nicotinamide 
• 935445-76-4 6-({2-[(4-chlorophenyl)amino]-2-oxoethyl}thio)-5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}nicotinamide 
• 935445-78-6 6-({2-[(4-tolyl)amino]-2-oxoethyl}thio)-5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}nicotinamide 

Relevant articles and documents

Acetoacetanilides in heterocyclic synthesis, Part 1: An expeditious synthesis of thienopyridines and other fused derivatives

3-Oxo-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}butanamide 1 reacts with arylidinecyanothioacetamide in refluxing ethanolic TEA to give the pyridinethione 2 rather than thiopyrane 4. Compound 2 reacts with α-haloketones to give the s-alkylated derivative