93546-53-3Relevant academic research and scientific papers
Synthesis of 4-Methyl-1-piperazino/piperidinobiguanidines as Oral Hypoglycemic Agents
Husain, M. I.,Srivastava, V. P.
, p. 789 - 792 (2007/10/02)
A series of N5-(4-aryl-5-arylazothiazol-2-yl- or 5-aryl-1,3,4-oxadiazol-2-yl-aminocarbonyl)-4-methyl-1-piperazino/piperidino-biguanidines (III-l and IVa-j) have been synthesised from N5-ethoxycarbonyl-4-methyl-1-piperazino/piperidino-biguanidines (IIa,b).The latter compounds in turn have been prepared by the reaction of N1-substituted biguanide hydrochlorides (Ia,b) with ethyl chloroformate.A few compounds of the series, when administered orally in rats, cause reduction in the blood sugar to a significant extent but most of these have been found to be toxic.
