34352-59-5

Usage

Uses

Used in Pharmaceutical Industry:
1-METHYLPIPERAZINE DIHYDROCHLORIDE is used as a chemical intermediate for the synthesis of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone (MPMAP), an antimicrotubular drug. This application is due to its ability to contribute to the development of effective treatments for various medical conditions.
Used in Chemical Synthesis:
1-METHYLPIPERAZINE DIHYDROCHLORIDE is used as a reagent in the preparation of 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate. This application highlights its versatility in chemical reactions and its importance in creating new compounds with potential applications in various fields.

InChI:InChI=1/C5H12N2.2ClH/c1-7-4-2-6-3-5-7;;/h6H,2-5H2,1H3;2*1H

Upstream product

• 2055-46-1 3,4,5,6-tetrahydropyrimidine-2-thione 
• 42951-91-7 2-chloro-1-(4-methylpiperazin-1-yl)ethan-1-one hydrochloride 
• 93378-52-0 1-methyl-4-(2-tetrahydropyrimidinylthioacetyl)piperazine dihydrochloride 
• 62226-74-8 1-benzyl-4-methylpiperazine 
• 109-01-3 1-methyl-piperazine 
• 5625-52-5 1-methylpiperazin-2,5-dione 
• 7647-01-0 hydrogenchloride 
• 93378-54-2 1-methyl-4-(2-tetrahydro-1,3-diazepinylthioacetyl)piperazine dihydrochloride 

Downstream Products

• 28920-67-4 1-(2-ethoxy-2-oxoethyl)-4-methylpiperazine 
• 60868-01-1 3-(4-methylpiperazin-1-yl)-1-phenylpropan-1-one 
• 74976-33-3 3-(4-methyl-1-piperazinylmethyl)-6-chloro-5-azaindole 
• 13993-24-3 1,4-bis(2-benzoylethyl)piperazine 
• 75956-17-1 2-Methyl-6-[2-(4-methyl-piperazin-1-yl)-ethyl]-4-o-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 75956-05-7 2-Methyl-6-[2-(4-methyl-piperazin-1-yl)-ethyl]-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 111837-85-5 1-benzyl-3-(4'-methylpiperazinyl-1'-methyl)-4-methyl-5-cyano-6-chloro-7-azaindole 
• 139755-83-2 viagra 
• 60868-03-3 1-(4-methoxy-phenyl)-3-(4-methyl-piperazin-1-yl)-propan-1-one 
• 18413-26-8 4-methylpiperazin-1-yl-biguanidine dihydrochloride 
• 33860-28-5 4-methylpiperazine-1-carbothioamide 
• 132502-06-8 1-[2-(2-benzyl-phenoxy)-ethyl]-4-methyl-piperazine 
• 102166-95-0 1-(2-benzhydryloxy-ethyl)-4-methyl-piperazine 
• 100316-89-0 3-(4-methyl-piperazino)-1-[2]thienyl-propan-1-one 

Relevant academic research and scientific papers

Highly chemoselective Pd-C catalytic hydrodechlorination leading to the highly efficient N-debenzylation of benzylamines

(Equation Presented) In the presence of 1,1,2-trichloroethane, a novel procedure for the Pd-C catalytic N-debenzylation of benzylamines was established. The method proceeded in a synergistic catalytic system and directly gave the products as crystal amine hydrochlorides in practically quantitative yields.

7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE

The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them

Modular syntheses of multidentate ligands with variable N-donors: Applications to tri- and tetracopper(i) complexes

A general method for the preparation of multidentate ligands comprised of a multi-imine platform derived from 1,1,1-tris(aminomethyl)ethane or tris(aminoethyl)amine connected to bi- and tridentate N-donor chelates has been developed. The feasibility of the method has been demonstrated through the synthesis and characterization of a large set of these ligand types. Complexation to Cu(i) was accomplished for several cases, yielding tri- and tetracopper(i) complexes that have been characterized in solution by NMR spectroscopy and conductivity, and in the solid state by elemental analysis, mass spectrometry, and/or X-ray crystallography. These complexes are potentially useful for modeling multicopper protein active sites. The Royal Society of Chemistry.

Isotopically enriched N-substituted piperazines and methods for the preparation thereof

In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines.

Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof

In some embodiments, this invention pertains to isotopically enriched N-substituted piperazine acetic acids. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazine acetic acids.

Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient

The present invention is a piperazinylalkylbenzofuran derivative of the formula wherein R1 represents a C1-4 alkyl group, R2 stands for a hydrogen atom, X means an oxygen atom, Y is a hydroxyl group, Z represents a hydrogen atom, Ar′ represents a diphenylmethyl group, a pyridyl group, a partially saturated 5-membered heterocyclic group or a phenyl group, n has a value of 0 or 1, and pharmaceutically suitable acid addition salts thereof.

1-phenyl-3-(1-piperazinyl)-1H-indazoles

Novel 1-phenyl-3-(1-piperazinyl)-1H-indazoles, intermediates and processes for the preparation thereof, and methods for alleviating pain, treating convulsions, and treating depression utilizing compounds or compositions thereof are disclosed.

REACTION OF CYCLIC THIOUREAS WITH CHLOROACYLPIPERAZINES

S-Alkylation products are formed in the reaction of tetrahydropyrimidine-2-thione and hexahydro-1,3-diazepine-2-thione with chloroacylpiperazines in dimethylformamide at room temperature; dihydrothiazolopyrimidine and tetrahydrothiazolo-diazepine systems are obtained in refluxing ethanol.It is shown that the S-alkyl derivatives are very readily converted to condensed systems.