93548-84-6Relevant academic research and scientific papers
A new approach to the synthesis of rare thiazino[6,5-b]indol-4-one derivatives. First total synthesis of the indole phytoalexin cyclobrassinon
Kutschy, Peter,Suchy, Mojmír,Andreani, Aldo,Dzurilla, Milan,Ková?ik, Vladimír,Alf?ldi, Juraj,Rossi, Maddalena,Gramatová, Mária
, p. 9029 - 9039 (2007/10/03)
The first synthesis of the indole phytoalexin cyclobrassinon and some of its analogues, possessing a thiazino[6,5-b]indol-4-one tricyclic ring system was performed starting from 1-substitued 2-chloroindole-3-carboxaldehydes. The route employed the intramolecular Et3N-mediated or photochemical nucleophilic substitution of a chlorine atom in the 2-position of the indole ring with a sulfur atom as a key step. Examination of biological activity against the selected tumor cell lines, bacteria and fungi revealed no expressive activity of synthesized compounds.
A new photocyclization approach to the rare 1,3-thiazino[6,5-b]indol-4-one derivatives
Kutschy, Peter,Suchy, Mojmír,Andreani, Aldo,Dzurilla, Milan,Rossi, Maddalena
, p. 9281 - 9283 (2007/10/03)
The analogs of indole phytoalexin cyclobrassinon have been prepared in four steps from corresponding 1-substituted 2-chloroindole-3-carboxylic acids, employing a hitherto unknown photochemical cyclization of new indolyl thiocarbamates to 1,3-thiazino[6,5-b]indole-4-one derivatives as a key step.
Potential antitumor agents. XIII. Indole derivatives related to Lonidamine
Andreani,Rambaldi,Bonazzi,Andreani,Bossa,Galatulas
, p. 847 - 851 (2007/10/02)
The synthesis and the antitumor activities of 1-benzylindole-3-carboxylic acids are reported. Compound 16b, which bears at position 1 the same substituent as Lonidamine (1), proved to be the most active derivative.
