77655-46-0

Upstream product

• 221642-05-3 1-Benzyl-3-dimethylaminomethylene-2,3-dihydro-1H-indol-2-one 
• 5059-30-3 2-chloroindole-3-carboxaldehyde 
• 57315-91-0 3-Dimethylaminomethylene-2,3-dihydro-1H-indol-2-one 
• 100-44-7 benzyl chloride 
• 114538-03-3 3-Chloroylmethylene-2,3-dihydro-1H-indol-2-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 126177-54-6 1-Benzyl-2-azido-1H-indole-3-carbaldehyde 
• 93548-84-6 1-Benzyl-2-chloro-1H-indole-3-carboxylic acid 
• 221642-21-3 9-benzyl-2-(2,6-dimethyl-hept-5-enyl)-9H-1,3,9-triaza-fluorene 
• 1310128-95-0 C₁₆H₁₄ClNO 
• 85753-43-1 staurosporine aglycone 

Relevant academic research and scientific papers

Synthesis and Antimicrobial Activities of Novel Quinazolinone Acylhydrazone Derivatives Containing the Indole Moiety

A series of novel quinazolinone acylhydrazone derivatives containing the indole moiety were designed, synthesized, and evaluated for their inhibition activities against some important phytopathogens in vitro. Antibacterial experiments indicated that some compounds exhibited remarkable inhibition activities against tested bacteria. Especially, the EC50 values of 7a (EC50?=?55.13?μg/mL against Xoo, EC50?=?56.92?μg/mL against Rs) demonstrated the best antibacterial activities against Xoo and Rs than the other compounds, and the control agents Bismerthiazol (EC50?=?89.80?μg/mL against Xoo) and Thiodiazole copper (EC50?=?189.52?μg/mL against Rs), moreover, compound 7o (EC50?=?50.80?μg/mL) displayed the excellent activity against Xac than the control Bismerthiazol (EC50?=?56.92?μg/mL).

Tandem copper (Cu) catalysed N-arylation-vinylogous nitroaldol condensation of 3,5-disubstituted 4-nitropyrazoles

A tandem process involving copper catalysed N-arylation and vinylogous nitroaldol condensation is described. The reaction of 3,5-dialkyl substituted 4-nitropyrazoles and ortho-halo substituted (hetero)aryl aldehydes or ketones furnished 3-nitropyrazolo[1,5-a]quinoline and heteroaryl-fused 3-nitropyrazolo[1,5-a]pyridine derivatives in moderate to high yields.

Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)

The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

v-Triazolines. Part 41. A new synthesis of 2-alkylquinazolines and 2,9-dialkylpyrimido[4,5-b]indoles

2-Alkylquinazolines were obtained from amidines by reaction with ammonia. The synthesis has been applied to the preparation of 2,9-dialkylpyrimido[4,5-b]indoles, in a one pot reaction, from 1-alkyl-2-azidoindole-3-carbaldehydes, a secondary amine and aldehydes and reaction with ammonia.

ANTAGONISTS, THEIR PREPARATION AND USE

The present invention relates to therapeutically active non competitive antagonists, acting selectively at the metabotropic glutamate receptor. The novel compounds are useful in treating diseases in the central nervous system by modulating synaptic transmission via the metabotropic glutamate receptor.

THIENO[2,3-B-INDOLE DERIVATIVES AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES RELATED TO THE METABOTROPIC GLUTAMATE RECEPTOR SYSTEM

The present invention relates to therapeutically active heterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system related to the metabotropic glutamate receptor system.

SINTESI ED ATTIVITA ANTIBATTERICA IN VITRO DI N-METILNITRONI E NITROVINILI DERIVATI DA ALCUNE 2-CLOROINDOL-3-CARBOSSIALDEIDI N-SOSTITUITE

N-methylnitrones and nitrovinyl derivatives from 1-substituted-2-chloroindole-3-carboxaldehydes were synthesized and evaluated for their in vitro antibacterial activity.Some nitrovinyl derivatives displayed good in vitro activity against Gram-positive bacteria; the compound (II e), 1-(o-chlorobenzyl)-2-chloro-3-(2-nitroethenyl)indole, was more active than nitrofurantoin against Staphylococcus aureus and Streptococcus pyogenes.Some structure-activity relationships are discussed.