93548-90-4

Upstream product

• 5059-30-3 2-chloroindole-3-carboxaldehyde 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 75621-51-1 1-(4-Chlorobenzyl)-2-chloroindole-3-carboxaldehyde 

Downstream Products

• 120110-20-5 1-[2-Chloro-1-(4-chloro-benzyl)-1H-indole-3-carbonyl]-3-(4-chloro-phenyl)-urea 
• 120110-14-7 2-Chloro-1-(4-chloro-benzyl)-1H-indole-3-carboxylic acid amide 

Relevant academic research and scientific papers

N-Benzyl-2-chloroindole-3-carboxylic acids as potential anti-inflammatory agents. Synthesis and screening for the effects on human neutrophil functions and on COX1/COX2 activity

The synthesis of N-benzyl-2-chloroindole-3-carboxylic acids related to indomethacin is reported. These compounds were tested on in vitro human neutrophil activation. Some of them, more soluble in water, were tested to define the influence on prostaglandin biosynthesis via inhibition of cyclooxygenases (COX1 and COX2) by a chemiluminescent method suitable for fast screening. Several derivatives showed inhibitory effects and in some cases were more active than the parent compound.

Potential antitumor agents. XIII. Indole derivatives related to Lonidamine

The synthesis and the antitumor activities of 1-benzylindole-3-carboxylic acids are reported. Compound 16b, which bears at position 1 the same substituent as Lonidamine (1), proved to be the most active derivative.