93579-02-3

Basic information

• Product Name: Benzeneacetic acid, 2-bromo-, butyl ester
• CAS NO: 93579-02-3
• Molecular Formula: C12H15BrO2
• Molecular Weight: 271.154
• Mol File: 93579-02-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 2-bromo-, butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-bromo-, butyl ester(93579-02-3)
• EPA Substance Registry System: Benzeneacetic acid, 2-bromo-, butyl ester(93579-02-3)

Safety Data

• Hazardous Substances Data: 93579-02-3(Hazardous Substances Data)

Upstream product

• 109-69-3 n-Butyl chloride 
• 63071-77-2 potassium 2-bromophenylacetate 
• 688-74-4 boric acid tributyl ester 
• 201230-82-2 carbon monoxide 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 1632260-39-9 butyl 2-(3-bromophenyl)-2-diazoacetate 

Relevant articles and documents

Regioselectivity of intramolecular rhodium-catalyzed c-h insertion reactions of α-aryl-α-diazocarboxylates: Influence of the aryl substituent

It was found that α-aryl-α-diazocarboxylates react with variable regioselectivity in intramolecular rhodium-catalyzed C-H insertion reactions. 3-(Trialkoxysilyl)propyl esters underwent a clean cis-γ-lactone formation (62-69%) if the aryl rest was a phenyl group while the analogous α-(2-bromophenyl)-α-diazocarboxylates produced the respective β-lactones. In general β-lactone formation was shown to be the only detectable C-H insertion pathway for the latter substrate class irrespective of the ester substituent. The β-lactone products (eight examples) were obtained in yields of 41-68% with a diastereomeric ratio (dr) of 75:25 to 96:4 in favor of the trans diastereoisomer. The 2-bromo substituent could be displaced by an aryl group in a subsequent Suzuki cross-coupling reaction. Georg Thieme Verlag Stuttgart New York.