93583-97-2

Upstream product

• 55933-85-2 acetyl-5 dimethyl-2,4 pyrimidine 
• 2582-30-1 aminoguanidine bicarbonate 
• 66373-27-1 acetyl-5 methyl-4 phenyl-2 pyrimidine 
• 1937-19-5 1-aminoguanidine hydrochloride 
• 87379-42-8 5-acetyl-4-methylpyrimidine 
• 66373-26-0 1-(4-methyl-2-methylsulfanylpyrimidin-5-yl)ethanone 

Downstream Products

• 93584-00-0 4-acetyl-1-amidino-3-methylpyrazole hydrochloride 
• 105224-04-2 1-(3-methyl-1H-pyrazol-4-yl)ethanone 
• 93583-99-4 3-methyl-4-pyrazolyl methylketone amidinohydrazone hydrochloride 

Relevant academic research and scientific papers

Synthese regiospecifique d'acyl-4 pyrazoles a partir d'acyl-5 pyrimidines

The transformation of variously substituted 5-acetyl-4-methylpyrimidines 1 into 4-acetyl-1-amidino-3-methylpyrazole amidinohydrazone dihydrochloride 3, under the action of amidinohydrazine hydrochloride, in boiling acidic methanolic solution, depends on the nature of the 2-substituent of pyrimidines 1, and on the stability of the amidinohydrazone of pyrimidines 2 under the reaction conditions.Phenylhydrazine transforms all the pyrimidines 1 into pyrazoles, regiospecifically or not, according to the nature of the 2-substituent of pyrimidines 1.This new possibility of ring contraction has been extended to other unsymetrical 5-acyl- and 5-ethoxycarbonylpyrimidines.

CONVERSION OF PYRIMIDINES INTO AMIDINOPYRAZOLE BY ACTION OF AMINOGUANIDINE HYDROCHLORIDE

Aminoguanidine hydrochloride reacts with pyrimidines of type 1 giving the unexpected 1-amidino-3-methyl-4-pyrazolyl methyl ketone amidinohydrazone dihydrochloride 2.