936031-63-9

Upstream product

• 100-39-0 benzyl bromide 
• 162188-27-4 (2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methyl-2-buten-1-ol 
• 114701-65-4 tert-butyldimethyl((3-methylbut-2-en-1-yl)oxy)silane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 144950-82-3 (E)-4-(t-butyl-dimethyl-silanyloxy)-2-methyl-but-2-enal 
• 556-82-1 3-methyl-2-buten-1-ol 

Downstream Products

• 444809-23-8 ((2S,3R)-3-Benzyloxymethyl-3-methyl-oxiranyl)-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxymethyl)-3,3-dimethyl-cyclohex-1-enyl]-methanone 
• 444809-22-7 ((2R,3R)-3-Benzyloxymethyl-3-methyl-oxiranyl)-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxymethyl)-3,3-dimethyl-cyclohex-1-enyl]-methanol 
• 1027739-76-9 ((2S,3R)-3-Benzyloxymethyl-3-methyl-oxiranyl)-[(R)-2-(3,4-dimethoxy-benzyloxymethyl)-6-hydroxy-3,3-dimethyl-cyclohex-1-enyl]-methanone 
• 444809-24-9 (2S,3S,8aR)-2-Benzyloxymethyl-5-(3,4-dimethoxy-benzyloxymethyl)-3-hydroxy-2,6,6-trimethyl-2,3,6,7,8,8a-hexahydro-chromen-4-one 
• 444809-25-0 (2S,3S,3aS,8aR)-2-Benzyloxymethyl-2,6,6-trimethyl-2,3,6,7,8,8a-hexahydro-5H-furo[2,3,4-de]chromene-3,3a-diol 
• 332888-38-7 (2S,3R)-(3-benzyloxymethyl-3-methyl-oxiranyl)-methanol 
• 62311-52-8 (2E) 1-benzyloxy-2-methyl-2-buten-4-ol 

Relevant academic research and scientific papers

Tetrasubstituted pyrrolidines via a tandem aza-Payne/hydroamination reaction

A facile tandem aza-Payne/hydroamination reaction of aziridinol is reported, which yields highly functionalized pyrrolidines. Addition of alkynyl Grignards to 2,3-aziridinals yields, in most cases, high syn to anti ratios of the aziridinol. Treatment of the syn-aziridinol with base leads initially to an aza-Payne rearrangement, which juxtaposes the amine and the alkyne in favorable orientation to complete the hydroamination. The anti-aziridinol undergoes the aza-Payne rearrangement, but cannot proceed further with the hydroamination. Copyright

Convergent enantioselective synthesis of the tricyclic core of phomactin A

(Matrix Presented) The tricyclic core of phomactin A was synthesized from 6,6-dimethyl-2-cyclohexen-1-one. Key reactions include the addition of a cyclohexenyllithium reagent to an epoxyaldehyde and a regioselective intramolecular epoxide opening to insta