936074-51-0

Basic information

• Product Name: 1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid
• Synonyms: 1-(5-Chloro-2-benzoxazolyl)-4-piperidinecarboxylic acid;1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid
• CAS NO: 936074-51-0
• Molecular Formula: C₁₃H₁₃ClN₂O₃
• Molecular Weight: 280.71
• Mol File: 936074-51-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 472.2 °C at 760 mmHg
• Flash Point: 239.4 °C
• Appearance: /
• Density: 1.431
• Vapor Pressure: 1.01E-09mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid(936074-51-0)
• EPA Substance Registry System: 1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid(936074-51-0)

Safety Data

• Hazardous Substances Data: 936074-51-0(Hazardous Substances Data)

Usage

General Description

1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid is a chemical compound with a complex structure consisting of a piperidine ring linked to a benzo[d]oxazole group with a chloro substituent at the 5th position. It also contains a carboxylic acid functional group attached to the piperidine ring. 1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid has potential applications in medicinal chemistry as it may exhibit pharmacological properties due to its structural features. It may be used in the synthesis of novel pharmaceutical agents or as a research tool in drug discovery and development. Additionally, it is important for researchers to further study its properties, potential uses, and safety considerations before any practical applications are pursued.

InChI:InChI=1/C13H13ClN2O3/c14-9-1-2-11-10(7-9)15-13(19-11)16-5-3-8(4-6-16)12(17)18/h1-2,7-8H,3-6H2,(H,17,18)

Upstream product

• 22876-19-3 5-chloro-2-mercaptobenzoxazole 

Downstream Products

• 1359985-36-6 C₂₀H₂₆ClN₃O₃ 

Relevant articles and documents

Novel benzoxazole inhibitors of mPGES-1

A novel series of potent benzoxazole mPGES-1 inhibitors has been derived from a hit from a high throughput screen. Compound 37 displays mPGES-1 inhibition in an enzyme assay (0.018 μM) and PGE-2 inhibition in a cell-based assay (0.034 μM). It demonstrates 500- and 2500-fold selectivity for mPGES-1 over COX-2 and 6-keto PGF-1α, respectively. In vivo PK studies in dogs demonstrate 55% oral bioavailability and an 7 h half-life.