936083-47-5Relevant academic research and scientific papers
Polyalkoxybenzenes from plant sources 2. Synthesis of isoxazoline analogs of combretastatin from natural allyl(methylenedioxy)methoxybenzenes
Tsyganov,Yakubov,Konyushkin,Firgang,Semenov
experimental part, p. 2460 - 2465 (2009/02/05)
A series of analogs of the natural mitostatic agent combretastatin were synthesized by the reaction of nitrile oxides with natural allylbenzenes, such as myristicin, apiol, and dillapiol. The 1,3-dipolar cycloaddition reactions in allylic systems proceed regiospecifically. The reactions with trans isomers of propenylbenzenes, viz., isomyristicin, isoapiol, and isodillapiol, as dipolarophiles produce regioisomers.
