936127-72-9

Upstream product

• 502424-52-4 C₁₃H₁₅FO₃ 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 797053-22-6 ethyl 5-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carboxylate 
• 100-63-0 phenylhydrazine 
• 1999-00-4 ethyl 3-(4'-fluorophenyl)-3-oxopropionate 

Downstream Products

• 1421848-87-4 5-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carboxamide 
• 1421848-88-5 5-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbothioamide 
• 1421848-90-9 ethyl {2-[5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate 
• 1421848-91-0 {2-[5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetic acid 
• 1421847-27-9 2-{2-[5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)acetamide 

Relevant academic research and scientific papers

Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004

New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.

HETEROCYCLIC COMPOUND

Provided is a heterocyclic compound having an RORγt inhibitory activity. A compound represented by the formula (I): wherein ring A is an optionally substituted cyclic group, Q is a bond, optionally substituted C1-10 alkylene, optionally substituted C2-10 alkenylene, or optionally substituted C2-10 alkynylene, R1 is a substituent, ring B is a thiazole ring, an isothiazole ring or a dihydrothiazole ring, each of which is optionally further substituted by a substituent in addition to R2, and R2 is an optionally substituted cyclyl-carbonyl-C1-6 alkyl group, an optionally substituted aminocarbonyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkylamino-carbonyl group, an optionally substituted aminocarbonyl-C2-6 alkenyl group, an optionally substituted C1-6 alkylcarbonylamino-C1-6 alkyl group, an optionally substituted cyclyl-aminocarbonyl group, an optionally substituted cyclyl-carbonyl group or an optionally substituted non-aromatic heterocyclic group, or a salt thereof.