93613-08-2Relevant academic research and scientific papers
Triazolopyrimidine derivative compounds
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, (2017/05/18)
PROBLEM TO BE SOLVED: To provide a FABP4 probe having low lipid solubility and capable of specifically binding to FABP4.SOLUTION: This invention relates to a triazolopyrimidine derivative compound comprising a fluorine atom or salt thereof, and a pharmaceutical composition comprising the same.
Access to 2-(het)aryl and 2-styryl benzoxazoles via palladium-catalyzed aminocarbonylation of aryl and vinyl bromides
Neumann, Karoline T.,Lindhardt, Anders T.,Bang-Andersen, Benny,Skrydstrup, Troels
supporting information, p. 2094 - 2097 (2015/05/13)
A sequential one-pot procedure for the synthesis of either 2-(hetero)aryl or 2-styryl benzoxazoles is reported, starting from aryl and vinyl bromides, respectively, involving an initial aminocarbonylation with 2-aminophenols as nucleophiles followed by an acid mediated ring closure to generate the heterocycle. The methodology displays a broad substrate scope in moderate to excellent yields and can be exploited for 13C-isotope labeling. Finally, this carbonylative protocol was applied to the synthesis of a potential Alzheimer's plaque binder and a selective PPAR antagonist including site-specific labeling with 13C-carbon monoxide.
Pesticidal 2-fluoroethyl ethers
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, (2008/06/13)
Pesticidal mono-, di-, and tri-2-fluoroethyl ethers of the formula R1 R2m Ar(OCH2 CH2 F)n, compositions thereof and their insecticidal, acaricidal and nematicidal uses are described and cla
