936138-17-9 Usage
General Description
3-Iodo-6-methoxy-1H-indazole is a chemical compound with the molecular formula C9H8INO and a molecular weight of 261.07 g/mol. It is a heterocyclic organic compound containing an indazole ring, which is a bicyclic structure composed of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrazole ring. 3-IODO-6-METHOXY-1H-INDAZOLE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has potential applications as a pharmaceutical intermediate and in medicinal chemistry research due to its unique structure and reactivity. Additionally, 3-iodo-6-methoxy-1H-indazole may also exhibit biological activity and be used in the development of new drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 936138-17-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,6,1,3 and 8 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 936138-17:
(8*9)+(7*3)+(6*6)+(5*1)+(4*3)+(3*8)+(2*1)+(1*7)=179
179 % 10 = 9
So 936138-17-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H7IN2O/c1-12-5-2-3-6-7(4-5)10-11-8(6)9/h2-4H,1H3,(H,10,11)
936138-17-9Relevant articles and documents
Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome
Lynch, Stephen M.,Devicente, Javier,Hermann, Johannes C.,Jaime-Figueroa, Saul,Jin, Sue,Kuglstatter, Andreas,Li, Hongju,Lovey, Allen,Menke, John,Niu, Linghao,Patel, Vaishali,Roy, Douglas,Soth, Michael,Steiner, Sandra,Tivitmahaisoon, Parcharee,Vu, Minh Diem,Yee, Calvin
, p. 2793 - 2800 (2013/07/05)
Using a structure based design approach we have identified a series of indazole substituted pyrrolopyrazines, which are potent inhibitors of JAK3. Intramolecular electronic repulsion was used as a strategy to induce a strong conformational bias within the ligand. Compounds bearing this conformation participated in a favorable hydrophobic interaction with a cysteine residue in the JAK3 binding pocket, which imparted high selectivity versus the kinome and improved selectivity within the JAK family.
