93622-87-8

Upstream product

• 93622-95-8 Benzyl 6-beta-Bromo-6-alpha-(ethoxyaminomethyl)penicillanate 1,1-Dioxide 
• 75-09-2 dichloromethane 
• 7732-18-5 water 
• 76454-56-3 benzyl bromopenicillanate-S,S-dioxide 
• 76454-57-4 (pivaloyloxy)methyl 6,6-dibromopenicillanate S,S-dioxide 
• 93622-89-0 ethyl formaldoxime 

Relevant academic research and scientific papers

SYNTHETIC AND MECHANISTIC STUDIES INVOLVING THE CONDENSATION OF PENICILLIN GRIGNARDS AND BORON TRIFLUORIDE ACTIVATED OXIME ETHERS

High stereocontrol is observed in the BF3 mediated condensation of anions derived from mono and dibromopenicillanic ester sulfones and oxime ethers.

Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives

6-alpha/beta-[(C1 -C4)Alkoxyaminomethyl and benzyloxyaminomethyl]penicillanic acid 1,1-dioxides, pharmaceutically acceptable salts thereof and conventional esters thereof hydrolyzable under physiological conditions, all of which are

6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor

6-alpha- and 6-beta-(Aminomethyl)penicillanic acid, 1,1-dioxide esters which are hydrolyzable under physiological conditions, particularly those wherein the ester radical is 1H-isobenzofuran-3-on-1-yl or (5-methyl-1,3-dioxol-2-on-4-yl)methyl, and an improved process and intermediates used in their synthesis.

Process for debromination of dibromopenicillanic acid and derivatives

A process for the debromination of 6-monobromo- and 6,6-dibromopenicillanic acid, and various derivatives thereof, by the action of a bisulfite salt. The debrominated compounds produced find various utilities, as beta-lactamase inhibitors useful in therapy in combination with known beta-lactam antibiotics, or as intermediates in the further synthesis of useful beta-lactam compounds.