936226-36-7

Basic information

• Product Name: bi[(2S,4S)-2-dimethylaminocarbonyl-1-PNZ-pyrrolindin-4-yl]disulfide
• Synonyms: bi[(2S,4S)-2-dimethylaminocarbonyl-1-PNZ-pyrrolindin-4-yl]disulfide
• CAS NO: 936226-36-7
• Molecular Weight: 704.782
• Mol File: 936226-36-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: bi[(2S,4S)-2-dimethylaminocarbonyl-1-PNZ-pyrrolindin-4-yl]disulfide(CAS DataBase Reference)
• NIST Chemistry Reference: bi[(2S,4S)-2-dimethylaminocarbonyl-1-PNZ-pyrrolindin-4-yl]disulfide(936226-36-7)
• EPA Substance Registry System: bi[(2S,4S)-2-dimethylaminocarbonyl-1-PNZ-pyrrolindin-4-yl]disulfide(936226-36-7)

Safety Data

• Hazardous Substances Data: 936226-36-7(Hazardous Substances Data)

Upstream product

• 96034-64-9 (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine 
• 96034-61-6 4-Nitrobenzyl (2S,4S)-4-(acetylthio)-2-[(dimethylamino)carbonyl]pyrrolidine-1-carboxylate 

Downstream Products

• 96034-64-9 (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine 

Relevant articles and documents

Preparation method of meropenem side chain disulfide

The invention discloses a preparation method of meropenem side chain disulfide. The method is characterized by comprising the following step that oxidative dehydrogenation reaction is performed in oxygen atmosphere by using meropenem side chains shown as

A PROCESS FOR THE PREPARATION OF MEROPENEM

The invention relates to a process for the preparation of meropenem, a β-methylcarbopenem. The said process comprises the following steps: preparing the compound of Formula (XI) from the compound of Formula (IV) through three steps "one-pot process"; then condensing the compound of Formula (XI) with the compound of Formula (XX) to form the compound of Formula (XXIV); finally preparing meropenam of Formula (I) from the compound of Formula (XXIV) by deprotection reaction by means of catalyst. The process of the invention is easily to carry out, the product is isolated in high content and yield, and the cost is reduced, thereby overcoming the shortage of the prior art.