936231-76-4Relevant academic research and scientific papers
Analogues of Acifran: Agonists of the high and low affinity niacin receptors, GPR109a and GPR109b
Jung, Jae-Kyu,Johnson, Benjamin R.,Duong, Tracy,Decaire, Marc,Uy, Jane,Gharbaoui, Tawfik,Boatman, P. Douglas,Sage, Carleton R.,Chen, Ruoping,Richman, Jeremy G.,Connolly, Daniel T.,Semple, Graeme
, p. 1445 - 1448 (2007/10/03)
Recently identified GPCRs, GPR109a and GPR109b, the high and low affinity receptors for niacin, may represent good targets for the development of HDL elevating drugs for the treatment of atherosclerosis. Acifran, an agonist of both receptors, has been tested in human subjects, yet until recently very few analogs had been reported. We describe a series of acifran analogs prepared using newly developed synthetic pathways and evaluated as agonists for GPR109a and GPR109b, resulting in identification of compounds with improved activity at these receptors.
Rhodium-catalyzed addition of aryl boronic acids to 1,2-diketones and 1,2-ketoesters
Ganci, Gregory R.,Chisholm, John D.
, p. 8266 - 8269 (2008/03/14)
The metal complex Rh(acac)(CO)2 in the presence of dicyclohexylphenylphosphine provides a useful catalyst system for the addition of boronic acids to 1,2-diketones and 1,2-ketoesters. The best yields were obtained when the transformation was pe
