936232-22-3

Usage

Uses

Used in Pharmaceutical Industry:
Rivaroxaban Impurity 12 is used as a research compound for the development and evaluation of antithrombotic agents. It helps in understanding the metabolism and pharmacokinetics of Rivaroxaban, which is a direct FXa inhibitor, and contributes to the advancement of novel antithrombotic therapies.

Upstream product

• 100-01-6 4-nitro-aniline 
• 75-21-8 oxirane 
• 482308-02-1 N-{[(5S)-3-(4-aminophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-5-chloro-2-thiophenecarboxamide 
• 936232-12-1 N-[((5S)-3-{4-[(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]-5-chlorothiophene-2-carboxamide 

Downstream Products

• 366789-02-8 Rivaroxaban 
• 936232-24-5 N-[((5S)-3-{4-[[(benzoylamino)carbonothioyl](2-hydroxyethyl)amino]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]-5-chlorothiophene-2-carboxamide 

Relevant academic research and scientific papers

Preparation method of rivaroxaban

The invention relates to a preparation method of rivaroxaban, in particular to a method for efficiently synthesizing rivaroxaban by taking p-nitroaniline and (S)-N-glycidol phthalimide as raw materials through seven steps: an addition reaction, a cyclization reaction, a hydrolysis reaction, an amidation reaction, a reduction reaction, an addition reaction and a cyclization reaction. The provided rivaroxaban preparation method has the advantages of high yield, low cost, few three wastes, and high product purity and is suitable for industrialization.

Phenylene-Bis-Oxazolidine Derivatives and Their Use as Anticoagulants

The present application relates to novel 1,4-phenylene-bis-oxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or