936234-38-7Relevant articles and documents
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists
Selvam, Chelliah,Oueslati, Nadia,Lemasson, Isabelle A.,Brabet, Isabelle,Rigault, Delphine,Courtiol, Tiphanie,Cesarini, Sara,Triballeau, Nicolas,Bertrand, Hugues-Olivier,Goudet, Cyril,Pin, Jean-Philippe,Acher, Francine C.
experimental part, p. 2797 - 2813 (2010/08/06)
(R)-PCEP (3-amino-3-carboxypropyl-2′-carboxyethyl phosphinic acid, 1), a new metabotropic glutamate receptor 4 (mGlu4R) agonist, was discovered in a previously reported virtual screening. The (S)-enantiomer and a series of derivatives were synthesized and