14273-85-9

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 4-IODOBUTYRATE is used as a reagent for the synthesis of 4-[formyl-5-(methoxymethyl)-1H-pyrrol-1-yl] butanoic acid, which is an important intermediate in the development of pharmaceutical compounds.
Used in Biochemical Research:
METHYL 4-IODOBUTYRATE is used in the synthesis of a range of stable S-adenosylmethionine (SAM) mimetics. These mimetics are valuable tools in studying the role of SAM in various biological processes and have potential applications in the development of new drugs and therapies.
Used in Molecular Biology:
The ability of METHYL 4-IODOBUTYRATE-derived compounds to promote the binding of the E. coli methionine repressor (MetJ) to its operator DNA has been investigated. This research contributes to the understanding of gene regulation mechanisms and can potentially lead to the development of novel strategies for controlling gene expression in various organisms.

InChI:InChI=1/C5H9IO2/c1-8-5(7)3-2-4-6/h2-4H2,1H3

Upstream product

• 67-56-1 methanol 
• 7425-27-6 4-iodobutanoic acid 
• 591235-25-5 ω-Diazo-buttersaeuremethylester 
• 96-48-0 4-butanolide 
• 3153-37-5 methyl 4-chlorobutyrate 
• 925-57-5 methyl 4-hydroxybutanoate 
• 4897-84-1 Methyl 4-bromobutyrate 

Downstream Products

• 93478-72-9 γ-(N,N-Dicyclohexylamino)-buttersaeure-methylester 
• 92196-82-2 4--buttersaeure-methylester 
• 109386-71-2 methyl 4-(N-benzyl-N-(2-methoxycarbonylethyl))aminobutyrate 
• 76798-14-6 methyl 5-cyano-5-(3-methoxyphenyl)heptanoate 
• 133042-97-4 methyl 4-(p-tolylsulfonyl)butanoate 
• 78429-22-8 methyl 5-oxo-8-phenyloctanoate 
• 1821-12-1 4-Phenylbutyric acid 
• 98582-10-6 7-{(1R,2R,3R,5S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-cyclopentyl}-6-oxo-5-phenylsulfanyl-heptanoic acid methyl ester 
• 244638-16-2 2-(4-chlorophenyl)-2,5-dihydro-7-(3-methoxycarbonylpropyl)-6-methylpyrazolo[4,3-c]pyridin-3-one 
• 47312-26-5 (S)-2-Benzyloxycarbonylamino-heptanedioic acid 7-methyl ester 
• 118436-64-9 (5E,11Z,13E)-15-(tert-Butyl-diphenyl-silanyloxy)-2,9,9-tris-methoxycarbonyl-6-methyl-pentadeca-5,11,13-trienoic acid methyl ester 
• 118427-88-6 (5E,11Z,13E)-15-(tert-Butyl-diphenyl-silanyloxy)-9,9-bis-methoxycarbonyl-6-methyl-pentadeca-5,11,13-trienoic acid methyl ester 
• 49637-21-0 4-(pyrrolidin-1-yl)butanoic acid hydrochloride 
• 59467-03-7 methyl 4-(dimethylphenylsilyl)butanoate 

Relevant academic research and scientific papers

Ni-Catalyzed Enantioselective Conjunctive Coupling with C(sp3) Electrophiles: A Radical-Ionic Mechanistic Dichotomy

The catalytic enantioselective conjunctive coupling of C(sp3) electrophiles can be accomplished with Ni catalysis. The enantioselectivity of the reaction is dependent on reaction mechanism with many substrates able to engage in an asymmetric process with Pybox-Ni complexes, whereas other substrates provide racemic product mixtures. The link between substrate structure and selectivity is addressed.

Catalyst-Free Reductive Coupling of Aromatic and Aliphatic Nitro Compounds with Organohalides

A rare reductive coupling of nitro compounds with organohalides has been realized. The reaction is initiated by a partial reduction of the nitro group to a nitrenoid intermediate. Therefore, not only aromatic but also aliphatic nitro compounds are efficiently transformed into monoalkylated amines, with organohalides as the alkylating agent. Given the innate reactivity of the nitrenoid, a catalyst is not required, resulting in a high tolerance for aryl halide substituents in both starting materials.

Phosphorothioic acids and related compounds as surrogates for H 2S-synthesis of chiral tetrahydrothiophenes

The convenient preparation of chiral tetrahydrothiophenes (THTs) in high enantiopurity via phosphorothioic acids and related compounds is reported. We consider these to be safer alternatives to the use of H2S which is a highly toxic gas. Each o

WATER-SOLUBLE CANNABINOIDS

Water-soluble cannabinoid compounds that are agonists of CB1 and CB2 cannabinoid receptors are provided. The compounds are made water-soluble by derivatization of the alkyl side chain and/or the phenolic hydroxyl group of tetrahydroc

Benzimidazole derivatives

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.

5-thia-ω-substituted phenyl-prostaglandin E derivatives, process for producing the same and drugs containing the same as the active ingredient

The present invention relates to 5-thia-ω-substituted phenylprostaglandin E derivatives of the formula (I) (wherein, all the symbols are as defined in the specification), process for producing them and pharmaceutical compositions comprising them as active

Fumarate salt of 4-(diethyl-3-(1-methyloctyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol, 4-(diethyl-amino) butyric

The present invention provides the fumarate salt of 4-(diethyl-3-(1-methyloctyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol, 4-diethyl-amino)butyric acid ester, i.e. the compound having the following structure (I): STR1 and methods of t

Stereocontrolled construction of 1, 7-dimethyl A.B.C.[6.6.6] tricycles. Part I. transannular Diels-Alder reactions of 14-membered macrocycles containing frans-dienophiles

Transannular Diels-Alder reactions of 14-membered macrocyclic trienes possessing a methyl substituent on both the diene and dienophile moiety have been investigated. Macrocyclic structures la, lb, and lc having cis-trans-trans (CTT), trans-cis-trans (TCT), and trans-trans-trans (TTT) geometries could be stereoselectively constructed by coupling appropriately functionalized dienes 5 and dienophile 4 following an intramolecular displacement of an allylic halide by the anion of an appropriately located dimethyl malonate unit. The transannular Diels-Alder reaction performed on la led to a mixture of four major tricyclic products, including 34 possessing the unexpected trans-anti-cis (TAC) stereochemistry. When heated at 300°C, macrocycle lb underwent an unique conversion via an ene-retroene, Diels-Alder process, producing the unexpected tricycle 41 (racemic form) containing five contiguous chiral centers. A rationale for the above experimental facts is presented. In contrast to the previous results, the transannular Diels-Alder reaction of macrocycle lc was straightforward, producing a 95% isolated yield of trans-anti-cis (TAC) tricycle 34. This investigation demonstrates a general methodology for the stereocontrolled synthesis of 1, 2-dimethyl A.B.C[6.6.6] tricyclic compounds, which are potential precursors to polycyclic natural products such as steroids and terpenes.