93632-68-9Relevant academic research and scientific papers
Asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens
Hatzakis, Nikos S.,Smonou, Ioulia
, p. 325 - 337 (2007/10/03)
A new asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens has been found. Although alcohols are not the natural substrates for this enzyme, a high R enantioselectivity was observed. Stereochemical studies showed that variations in substrate structure lead to strong variations in enantioselectivity. The highest enantioselectivities are obtained when the β-carbon of the secondary alcohol is tertiary or quaternary.
Building blocks for the preparation of enantiomerically pure drugs containing a phenylalkylamine moiety
Bracher,Litz
, p. 591 - 593 (2007/10/02)
The enantiomers of chiral drugs may exhibit distinctly different pharmacokinetic and pharmacodynamic properties. Thus, the application of pure enantiomers is desirable in most cases. Therefore, it is neccessary to know which enantiomer is the more advantageous one and to work out an economical large scale synthesis of this pure enantiomer. Biocatalytic transformations of prochiral compounds provide an easy and efficient access to chiral, non racemic compounds. Therefore, we fixed upon microbial reductions of carbonyl compounds as the key steps in the preparation of enantiomerically pure building blocks.
Electron transfer reactions from alkali metal surfaces to (+/-) and (S)-(-)-1,3-dimethoxy-1,1-diphenylbutane. Studies on 1,3-elimination
Walborsky, Harry M.,Murari, Martha Pass
, p. 2464 - 2470 (2007/10/02)
The 1,3-elimination of methoxide by carbanions generated from the reaction of (+/-)-1,3-dimethoxy-1,1-diphenylbutane with the alkali metals, lithium, sodium, and potassium, in various solvents was studied to determine the significance of cation-methoxyl c
