936333-83-4

Upstream product

• 1178-09-2 (3aR,4S,9R,9aR)-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydronaphtho[2,3-c]furan-1(3H)-one 
• 7677-24-9 trimethylsilyl cyanide 
• 518-28-5 podofilox 
• 138456-91-4 6,7-O,O-demethylene-4'-O-demethylepipodophyllotoxin 
• 6559-91-7 4'-demethylepipodophyllotoxin 

Relevant academic research and scientific papers

Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives

In order to explore the range of biological activities of the podophyllotoxin compound class, a novel series of derivatives of podophyllotoxin, which were conjugates containing stavudine and different structural podophyllotoxin analogues, were designed, synthesized, and evaluated for their anti-HIV-1 activities in vitro. Among these compounds, 19d and 19c showed the highest anti-HIV-1 activities with EC50 values of 0.17 and 0.29 μM and TI values of 466.9 and 354.5, respectively.