936349-47-2

Basic information

• Product Name: 1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-methoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-(2-pyridinylmethoxy)-
• CAS NO: 936349-47-2
• Molecular Formula: C36H39N3O4S
• Molecular Weight: 609.789
• Mol File: 936349-47-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-methoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-(2-pyridinylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-methoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-(2-pyridinylmethoxy)-(936349-47-2)
• EPA Substance Registry System: 1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-methoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-(2-pyridinylmethoxy)-(936349-47-2)

Safety Data

• Hazardous Substances Data: 936349-47-2(Hazardous Substances Data)

Usage

Molecular structure

The compound has a complex structure that includes an indole core, propanoic acid, substituted benzene rings, pyridine groups, thioether, and methoxy functional groups.

Indole core

The indole core is a key structural component of the compound, which is a bicyclic aromatic system consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing ring.

Propanoic acid

The compound contains a propanoic acid group, which is a three-carbon carboxylic acid with the chemical formula C3H5COOH.

Substituted benzene rings

The molecule features various substituted benzene rings, which are aromatic rings with one or more atoms or groups replaced by other atoms or groups, altering the chemical properties of the ring.

Pyridine groups

The compound contains pyridine groups, which are six-membered heterocyclic aromatic compounds containing nitrogen atoms.

Methoxy functional group

The compound also contains a methoxy group (-OCH3), which is an electron-donating group that can influence the compound's reactivity and properties.

Potential applications

The compound's properties and potential applications need further research and experimentation to be fully understood and explored.

Upstream product

• 936351-50-7 3-[3-tert-butylsulfanyl-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester 
• 136558-13-9 ethyl 5-t-butylthio-2,2-dimethyl-4-oxo-pentanoate 
• 1031435-33-2 methanesulfonic acid 4-(6-methoxy-pyridin-3-yl)-benzyl ester 
• 936349-15-4 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester 

Downstream Products

• 1147872-22-7 sodium 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate 
• 1147872-23-8 lithium 3-(5-(pyridin-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-(4-(2-methoxypyridin-5-yl)benzyl)indol-2-yl)-2,2-dimethylpropionate 
• 1147872-24-9 potassium 3-(5-(pyridin-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-(4-(2-methoxypyridin-5-yl)benzyl)indol-2-yl)-2,2-dimethylpropionate 

Relevant articles and documents

REDUCTION OF PRO-INFLAMMATORY HDL USING A LEUKOTRIENE INHIBITOR

A method involving the administration of a therapeutically effective amount of a leukotriene inhibitor, a pharmaceutically acceptable salt, a pharmaceutically acceptable N-oxide, a pharmaceutically active metabolite, a pharmaceutically acceptable prodrug, or pharmaceutically acceptable solvate thereof to a human for reducing a level of pro-inflammatory HDL in the human. Various examples of leukotriene inhibitors, including 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin- 3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2, 2-dimethyl-propionic acid, are disclosed for administration for the reduction of pro-inflammatory HDL in a human. Reduction of pro-inflammatory HDL by the leukotriene inhibitor may include conversion of at least a portion of pro-inflammatory HDL to anti-inflammatory HDL.

5-Lipoxygenase-activating protein inhibitors: Development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl] -5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103)

The potent and selective 5-lipoxygenase-activating protein leukotriene synthesis inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)- benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (11j) is described. Lead optimizati

5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.