93635-20-2

Upstream product

• 211946-05-3 (5R,6S)-6-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methyl-5,6-dihydro-pyran-2-one 
• 211946-04-2 (5R,6S)-6-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-((2R,5R)-2,5-dimethyl-pyrrolidin-1-yl)-5-methyl-5,6-dihydro-pyran-2-one 
• 211946-07-5 (8R,9S,10S)-1-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-9-hydroxy-8,10-dimethyl-undecan-5-one 
• 211946-06-4 (Z)-(8R,9S,10S)-1-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-9-hydroxy-8,10-dimethyl-undec-6-en-3-yn-5-one 
• 211946-03-1 (5R,6S)-4-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-6-((S)-2-hydroxy-1-methyl-ethyl)-5-methyl-5,6-dihydro-pyran-2-one 
• 193475-28-4 tert-Butyl-((2S,5R,6S)-6-isopropoxy-5-methyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane 
• 115458-78-1 [(E)-1-Benzenesulfonyl-2-((2S,3R,6S)-3-methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-vinyl]-trimethyl-silane 
• 93635-17-7 (2S,3R,6S)-2-Benzyloxymethyl-3-methyl-1,7-dioxa-spiro[5.5]undecane 
• 93635-18-8 ((2S,3R,6S)-3-Methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-methanol 
• 62761-90-4 α,α-bis(trimethylsilyl)methylphenyl sulfide 
• 193475-43-3 ((2S,5R,6S)-6-Isopropoxy-5-methyl-tetrahydro-pyran-2-yl)-methanol 
• 193475-31-9 (2S,3R,6S)-2-((Z)-2-Benzenesulfonyl-2-triethylsilanyl-vinyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-tetrahydro-pyran 
• 193475-30-8 (2S,3R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2-((Z)-2-phenylsulfanyl-2-triethylsilanyl-vinyl)-tetrahydro-pyran 
• 193475-37-5 (8R,9S,10R)-11-Benzenesulfonyl-1,9-bis-(tert-butyl-dimethyl-silanyloxy)-8,10-dimethyl-undec-3-yn-5-one 

Downstream Products

• 104307-03-1 C₅₇H₇₆O₁₂SSi 
• 95791-24-5 C₄₀H₅₆O₁₁S 
• 193475-39-7 (2S,3S,6S)-2-{2-[(4R,5S,6R)-6-Isopropyl-5-methoxy-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl]-[1,3]dithian-2-yl}-6-((2R,3R,6S)-3-methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-heptan-3-ol 
• 104307-05-3 C₅₁H₇₂O₁₀Si 
• 115352-18-6 C₇₄H₉₈O₁₅S 
• 115352-20-0 C₆₅H₈₈O₁₂ 
• 115352-13-1 C₅₇H₇₄O₁₂SSi 
• 115352-14-2 C₅₆H₈₀O₁₁Si 
• 115352-16-4 C₄₉H₇₂O₁₁Si 
• 115352-17-5 C₅₀H₇₄O₁₀Si 
• 115352-15-3 C₄₉H₇₄O₁₁Si 
• 95791-25-6 C₄₀H₅₄O₁₁S 
• 95791-32-5 C₃₄H₅₀O₉ 
• 95791-30-3 C₃₄H₅₂O₉ 

Relevant academic research and scientific papers

Synthesis of the C28 through C38 segment of okadaic acid using vinylogous urethane aldol chemistry: Part IV

The synthesis of the C-28 through C-38 segment of the marine natural product okadaic acid was accomplished employing a highly enantio- and diasteroselective aldol condensation reaction of a chiral vinylogous urethane enolate. The stereocenter at C-29 was addressed utilizing a diastereoselective hydroboration reaction.

Synthesis of Okadaic Acid-Tautomycin Hybrid

One of the three spiro-segments in the synthesis of okadaic acid was synthesized under a new heteroconjugate addition strategy. Successive coupling of this spiro-segment with two tautomycin-synthetic segments afforded a hybrid molecule between okadaic acid and tautomycin.

SYNTHESIS OF A MARINE POLYETHER TOXIN, OKADAIC ACID (3). SYNTHESIS OF SEGMENT C.

The title compound was divided into three retrosynthetic segments, A, B and C, by disconnecting two C-C bonds at C-14/15 and C-27/28.Synthesis of the segment C in the optically active natural form starting from a D-glucose derivatives is described.The key