93636-56-7Relevant academic research and scientific papers
Asymmetric Propargylic Radical Cyanation Enabled by Dual Organophotoredox and Copper Catalysis
Lu, Fu-Dong,Liu, Dan,Zhu, Lei,Lu, Liang-Qiu,Yang, Qian,Zhou, Quan-Quan,Wei, Yi,Lan, Yu,Xiao, Wen-Jing
supporting information, p. 6167 - 6172 (2019/04/17)
The first asymmetric propargylic radical cyanation was realized through a dual photoredox and copper catalysis. An organic photocatalyst serves to both generate propargyl radicals and oxidize Cu(I) species to Cu(II) species. A chiral Cu complex functions as an efficient organometallic catalyst to resemble the propargyl radical and cyanide in an enantio-controlled manner. Thus, a diverse range of optically active propargyl cyanides were produced with high reaction efficiency and enantioselectivities (28 examples, 57-97% yields and 83-98% ee). Moreover, mechanistic investigations including experiments and density functional theory calculations were performed to illustrate on the reaction pathway and stereochemical results.
Preparation of highly substituted tetrahydropyrans via a metal assisted dipolar cycloaddition reaction
Allart, Eric A.,Christie, Steven D. R.,Pritchard, Gareth J.,Elsegood, Mark R. J.
supporting information; experimental part, p. 7339 - 7341 (2010/06/14)
A range of highly substituted tetrahydropyrans have been prepared by reaction of a donor-acceptor cyclobutane, where the donor is a metal-alkyne complex, with an aldehyde under Lewis acid conditions.
