93637-75-3

Upstream product

• 59566-51-7 4-Nitroimidazole-1-acetic acid ethyl ester 

Downstream Products

• 1186048-65-6 4-(4-iodophenyl)-1-[(4-nitroimidazol-1-yl)acetyl]thiosemicarbazide 
• 1186048-57-6 1-[(4-nitroimidazol-1-yl)acetyl]-4-phenyl-thiosemicarbazide 
• 1186048-61-2 4-(4-methoxyphenyl)-1-[(4-nitroimidazol-1-yl)acetyl]thiosemicarbazide 
• 1186048-59-8 1-[(4-nitroimidazol-1-yl)acetyl]-4-(4-tolyl)-thiosemicarbazide 
• 1186048-63-4 4-(4-bromophenyl)-1-[(4-nitroimidazol-1-yl)acetyl]thiosemicarbazide 
• 1312699-98-1 C₁₃H₁₂N₆O₂S 
• 1312699-97-0 C₁₂H₁₀N₆O₂S 
• 1312699-96-9 C₁₂H₁₆N₆O₂S 
• 1312699-92-5 C₁₃H₁₁FN₆O₂S 
• 1312699-87-8 C₁₂H₉FN₆O₂S 
• 93637-69-5 (4-Nitro-imidazol-1-yl)-acetic acid [1-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-meth-(E)-ylidene]-hydrazide 

Relevant academic research and scientific papers

Synthesis and anti-helicobacter pylori activity of (4-nitro-1- imidazolylmethyl)-1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles

A series of [(4-nitro-1 H-imidazol-1-yl) methyl]-1,2,4-triazoles and 1,3,4-thiadiazoles were prepared and evaluated for their activity against sensitive and resistant H. pylori strains. Study of the structure-activity relationship of these series of compounds indicated that the type of nitroimidazole moiety and the pendent group on the heteroaryl analog dramatically impact the anti-H. pylori activity. In triazole series, compound 5d, containing a 4-methyl phenyl group on the triazole ring, was the most potent compound tested against both metronidazole-sensitive and-resistant strains at a concentration of 8 μg. TUeBITAK.

New Derivatives of Thiosemicarbazide and 1,2,4-Triazoline-5-thione with Potential Antimicrobial Activity

In the reaction of the hydrazide of (4-nitroimidazol-1-yl)acetic acid 1 with isothiocyanates, the respective thiosemicarbazide derivatives 2-6 were obtained. Further cyclization with 2% NaOH led to the formation of 3-[(4-nitroimidazol-1-yl)-methyl]-4-substituted-1,2,4-triazoline-5-thiones 7-11. The structures of all new products were confirmed by analytical and spectroscopic methods. Six compounds 2-5, 8, and 10 were screened for their in vitro activity against some species of aerobic bacteria and fungi. Compound 3 appears to be a promising precursor of agents with antibacterial activity against Micrococcus luteus.