936445-67-9Relevant academic research and scientific papers
Synthesis of the monomeric counterpart of marinomycin A
Amans, Dominique,Bareille, Laurianne,Bellosta, Veronique,Cossy, Janine
supporting information; experimental part, p. 7665 - 7674 (2010/01/15)
(Chemical Equation Presented) An efficient and highly convergent synthesis of the monomeric counterpart of the antitumor-antibiotic marine natural product marinomycin A was achieved by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo- and regioselective cross-metathesis to generate the (E)-configured C20-C21 double bond, and a Horner-Wadsworth-Emmons olefination followed by a Pd-catalyzed Stille cross-coupling to construct the tetraene moiety.
An efficient and stereoselective synthesis of the monomeric counterpart of marinomycin A
Amans, Dominique,Bellosta, Veronique,Cossy, Janine
, p. 1453 - 1456 (2008/02/03)
Equation presented The monomeric counterpart of marinomycin A, an antitumor-antibiotic marine natural product, was synthesized efficiently in 11 steps from the commercially available ethyl (R)-(-)-3-hydroxybutyrate. The strategy was highlighted by a cruci
