936475-45-5

Upstream product

• 10147-11-2 propargyl benzene 
• 622-79-7 benzyl azide 
• 100-39-0 benzyl bromide 
• 104-53-0 3-phenyl-propionaldehyde 
• 536-74-3 phenylacetylene 

Downstream Products

• 936475-52-4 [Pt(C₆H₃(CH₂NMe₂)2)(1,4-dibenzyl-1,2,3-triazole)](BF₄) 
• 1492757-69-3 C₁₇H₁₈N₃⁽¹⁺⁾*BF₄^(1-) 
• 74731-42-3 (1-benzyl-1H-1,2,3-triazol-4-yl)(phenyl)methanone 
• 74731-48-9 (3-Benzyl-3H-[1,2,3]triazol-4-yl)-phenyl-methanone 

Relevant academic research and scientific papers

From the molecule to the mole: improving heterogeneous copper catalyzed click chemistry using single molecule spectroscopy

Single molecule spectroscopy (SMS) inspired the optimization of a heterogeneous 'click' catalyst leading to enhanced yields of the Cu-catalyzed reaction of azides with terminal alkynes. Changes in SMS data after optimization confirm the improvements in catalyst performance.

LOW PRESSURE NANOWIRE MEMBRANE FOR CATALYTIC REACTIONS AND METHODS OF MAKING AND USING THE SAME

In embodiments a metal or metal alloy nanowires are assembled into a nanoporous membrane that can be used in methods for catalyzing various reactions under low pressures and achieving high flow rate of the reactions. In embodiments, the membranes of the d

Nickel-Catalyzed Azide-Alkyne Cycloaddition to Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water

Transition-metal-catalyzed or metal-free azide-alkyne cycloadditions are methods to access 1,4- or 1,5-disubstituted 1,2,3-triazoles. Although the copper-catalyzed cycloaddition to access 1,4-disubstituted products has been applied to biomolecular reaction systems, the azide-alkyne cycloaddition to access the complementary 1,5-regioisomers under aqueous and ambient conditions remains a challenge due to limited substrate scope or moisture-/air-sensitive catalysts. Herein, we report a method to access 1,5-disubstituted 1,2,3-triazoles using a Cp2Ni/Xantphos catalytic system. The reaction proceeds both in water and organic solvents at room temperature. This protocol is simple and scalable with a broad substrate scope including both aliphatic and aromatic substrates. Moreover, triazoles attached with carbohydrates or amino acids are prepared via this cycloaddition.

A facile one-pot metal-free synthesis of 1,4-disubstituted 1,2,3-triazoles

Abstract A 1,3-dipolar cycloaddition reaction of commercially available aldehydes with azides and secondary amines through a one-pot strategy has been developed. This method furnishes 1,4-disubstituted 1,2,3-triazoles in good to excellent yields and high

Synthesis of α-Keto-1,2,3-triazoles through copper iodide catalyzed oxygenation

Benzyltriazoles have been catalytically oxidized by using CuI and tert-butyl hydroperoxide to yield phenyl(1H-1,2,3-triazol-4-yl)methanone derivatives in good yields at room temperature. Benzyltriazoles have been catalytically oxidized by using CuI and tert-butyl hydroperoxide to yield phenyl(1H-1,2,3-triazol-4-yl)methanone derivatives in good yields at room temperature. Copyright

Synthesis of α-keto-1,2,3-triazoles through copper iodide catalyzed oxygenation

Benzyltriazoles have been catalytically oxidized by using CuI and tert-butyl hydroperoxide to yield phenyl(1H-1,2,3-triazol-4-yl)methanone derivatives in good yields at room temperature.

Debenzylation of functionalized 4- and 5-substituted 1,2,3-triazoles

A range of 4- and 5-substituted N-benzyl-1,2,3-triazoles have been submitted to debenzylation using Pd/C and hydrogen in the presence of 1,1,2-trichloroethane. Triazoles with oxygen-containing substituents are efficiently debenzylated under these conditio

Synthesis and biological activities of triazole derivatives as inhibitors of InhA and antituberculosis agents

InhA, the enoyl reductase from the mycobacterial type II fatty acid biosynthesis pathway, is a target for the development of novel drugs against tuberculosis. We exploited copper-catalyzed [3+2] cycloaddition between alkynes and different azides to afford 1,4-disubstituted triazole or α-ketotriazole derivatives. Several compounds bearing a lipophilic chain mimicking the substrate were able to inhibit InhA. Among them, 1-dodecyl-4-phenethyl-1H-1,2,3-triazole displayed a minimum inhibitory concentration inferior to 2 μg/mL against Mycobacterium tuberculosis H37Rv.

"Click" 1,2,3-triazoles as tunable ligands for late transition metal complexes

The potential of "click" 1,2,3-triazoles to act as mono-dentate ligands in late transition metal complexes is explored relative to other commonly-used Lewis bases and it is shown that their coordination strength, determined by their 1- and 4-substituents,