93655-27-7

Usage

Chemical class

Nonsteroidal anti-inflammatory drug (NSAID)

Common uses

Reduce pain, inflammation, and fever

Mechanism of action

Blocks the production of certain natural substances in the body that cause pain, inflammation, and fever

Prescribed conditions

Arthritis, ankylosing spondylitis, and gout

Availability

Prescription and over-the-counter forms

Safety profile

Good when used as directed

Potential side effects

Stomach bleeding, heart attack, or stroke (especially with long-term use or high doses)

Precaution

Use as directed by a healthcare professional to minimize the risk of side effects

Upstream product

• 52805-48-8 2-(Benzyloxy)-1-naphthaldehyde 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 2283-08-1 2-hydroxy-1-naphthalenecarboxylic acid 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 

Downstream Products

• 175293-39-7 2-(benzyloxy)-1-naphthamide 
• 175293-40-0 ethyl 2-(benzyloxy)-1-naphthamidate 
• 374924-82-0 3-hydroxy-4-{{1-[2-(benzyloxy)naphthalen-1-yl]methanoyl}amino}naphthalene-1-sulfonic acid 
• 175293-38-6 2-(benzyloxy)naphthalene-1-carboxyl chloride 

Relevant academic research and scientific papers

An efficient chemoselective etherification of phenols in polyfunctional aromatic compounds

A simple and efficient chemoselective alkylation of phenols in polyfunctional aromatic compounds with different alkyl halides in the presence of K2CO3/TBAB is reported. The method is successful with various hydroxy aromatic acids or oximes possessing other functional groups.

Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis

High-throughput screening for the induction of a luciferase reporter gene in a thrombopoietin (TPO)-responsive cell line resulted in the identification of 4-diazo-3-hydroxy-1-naphthalene-sulfonic acids as TPO mimics. Modification of the core structure and adjustment of unwanted functionality resulted in the development of (5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazines which exhibited efficacies equivalent to those of TPO in several cell-based assays designed to measure thrombopoietic activity. Furthermore, these compounds elicited biochemical responses in TPO-receptor-expressing cells similar to those in TPO itself, including kinase activation and protein phosphorylation. Potencies for the best compounds were high for such low molecular weight compounds (MW 50 values in the region of 1-20 nM.

Thiazoline acid derivatives

Thiazoline acids and derivatives useful as chelators of trivalent metals in therapeutic applications have been prepared.

Synthesis and biological evaluation of naphthyldesferrithiocin iron chelators

The synthesis and iron-clearing properties of the naphthyldesferrithiocins 2-(2'-hydroxynaphth-1'-yl)-Δ2-thiazoline-(4R)-carboxylic acid, 2-(2'- hydroxynaphth-1'-yl)-Δ2-thiazoline-(4S)-carboxylic acid, 2-(3'- hydroxynaphth-2'-yl)-Δ2-thiazoline-(4R)-carboxylic acid, and 2-(3'- hydroxynaphth-2'-yl)-Δ2-thiazoline-(4S)-carboxylic acid are described. While the bile duct-cannulated rat model clearly demonstrates that the 3'- hydroxynaphth-2'-yl compounds are orally active iron-clearing agents and the corresponding 2'-hydroxynaphthyl-1'-yl compounds are not, in the primate model none of the benz-fused desazadesferrithiocin analogues are active. Oral versus subcutaneous administration of these ligands strongly suggests that metabolism is a key issue in their iron-clearing properties and that these benz-fused desferrithiocins are not good candidates for orally active iron- clearing drugs.