93660-99-2

Upstream product

• 62056-85-3 Nα-diphenylphosphinyltryptophanylmethionyl(β-t-butyl)aspartylphenylalanine phenyl ester 
• 93627-84-0 methionyl(β-t-butyl)aspartylphenylalanine phenyl eater hydrochloride 
• 5609-54-1 (S)-3-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester; hydrochloride 
• 62056-84-2 Nα-diphenylphosphinylmethionyl(β-t-butyl)aspartylphenylalanine phenyl ester 
• 62056-70-6 Nα-diphenylphosphinylmethionyl(β-t-butyl)aspartylphenylalanine amide 
• 62056-80-8 Nα-diphenylphosphinyltryptophan methyl ester 
• 62056-81-9 Nα-diphenylphosphinyltryptophan 
• 62056-79-5 Nα-diphenylphosphinylmethionine methyl ester 
• 62056-82-0 Nα-dipnenylphosphinylmethionine 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 5241-67-8 H-Asp(O-tBu)-Phe-NH₂ 
• 62056-71-7 Nα-diphenylphosphinyltryptophanylmethionyl(β-t-butyl)aspartylphenylalanine amide 

Relevant academic research and scientific papers

Phosphinamides: A New Class of Amino Protecting Groups in Peptide Synthesis

Nα-Diphenylphosphinyl protected α-amino acids have been prepared from the corresponding methyl or benzyl esters using diphenylphosphinic chloride-N-methylmorpholine followed by mild alkaline hydrolysis or catalytic hydrogenolysis, respectively.The suitability of these derivatives for use in amide bond forming reactions and their stability during the customary manipulations of peptide synthesis have been exhaustively examined.Acid-catalysed removal of the diphenylphosphinyl group has also been studied, with the aid of 32.4 MHz 32P n.m.r. spectroscopy, and compatability of cleavage with tryptophan and methionine residues - in the absence of scavengers - has been demonstrated by the synthesis of the partially protected C-terminal tetrapeptide of gastrin, Cl(1-)H2(1+)Trp-Met-Asp(Ot-Bu)-PheNH2.