936628-13-6

Basic information

• Product Name: (-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylvalinamide
• Synonyms: (-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylvalinamide
• CAS NO: 936628-13-6
• Molecular Weight: 334.459
• Mol File: 936628-13-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylvalinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylvalinamide(936628-13-6)
• EPA Substance Registry System: (-)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylvalinamide(936628-13-6)

Safety Data

• Hazardous Substances Data: 936628-13-6(Hazardous Substances Data)

Upstream product

• 936627-92-8 (+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)valinamide 
• 74-88-4 methyl iodide 
• 640-68-6 D-Val-OH 
• 22838-58-0 Boc-D-Val-OH 
• 73371-96-7 2-<<(tert-butoxycarbonyl)oxy>imino>-2-phenylacetonitrile 

Relevant articles and documents

Synthesis and biological evaluation of chiral α-aminoanilides with central antinociceptive activity

Tocainide and related optically active chiral α-aminoanilides were synthesized and tested in vivo via the hot plate test to evaluate their central analgesic action. The aims of the study were to verify if a) the increase in lipophilicity, obtained by the introduction of an alkyl group on the steric center (3f-i), and the replacement of the C=O group with the C=S (10) group as well as the introduction of a methyl or ethyl group on the amidic nitrogen atom (8a-c) would produce an increase in central analgesic efficacy with respect to Tocainide; b) the 2,6-xylidide moiety is crucial for high analgesic activity (3b-e); c) the hydrogen atom bonded to the amidic nitrogen moiety is an essential pharmacophoric element for analgesic activity. Among all the synthesized compounds, 3f showed antinociceptive properties with a good enantioselective index.