93669-88-6Relevant articles and documents
A Concise Synthesis of Potential COX Inhibitor BRL-37959 and Analogs Involving Bismuth(III) Catalyzed Friedel?Crafts Acylation
Ahmed, Shamsul Arefin,Hinz, Damon J.,Jellen, Marcus J.,Hossain, M. Mahmun
, (2018)
We report the development of a concise method of synthesizing possible cyclooxygenase (COX) inhibitor BRL-37959, which is believed to be a potent nonsteroidal anti-inflammatory drug (NSAID). The four-step synthesis greatly increased the efficiency of compound production from commercially available salicylaldehydes. The synthesis involved an optimized, bismuth(III) trifluoromethanesulfonate catalyzed benzoylation of a benzofuran ring.
7-Aroyl-2,3-dihydrobenzofuran-3-carboxylic Acids and 7-Benzoyl-2,3-dihydrobenzothiophene-3-carboxylic Acids as Analgesic Agents
Boyle, Elizabeth A.,Mangan, Frank R.,Markwell, Roger E.,Smith, Stephen A.,Thomson, Michael J.,et al.
, p. 894 - 898 (2007/10/02)
The synthesis of a series of 7-aroyl-2,3-dihydrobenzofuran-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzothiophene-3-carboxylic acids is described.The isomeric 4-benzoyl-1,3-dihydrobenzofuran-1-carboxylic acid was also prepared.Compounds were
Anti-inflammatory and analgesic benzothiophene and benzafuran derivatives, compositions, and method of use therefor
-
, (2008/06/13)
Compounds of formula (I): STR1 wherein: Ar is phenyl optionally substituted in the o-, m- or p-position by C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, bromo, chloro or fluoro, pyrryl optionally N-substituted by C1-4 alkyl, 2-furyl or 2-thienyl either optionally substituted in the 3-, 4- or 5-position by methyl, chloro or bromo, or 3-furyl or 3-thienyl; X is oxygen, sulphur, sulphoxide or sulphone, Y is methylene, R1 and R3 are hydrogen or C1-4 alkyl, and R2 is hydrogen, C1-4 alkyl, fluoro, chloro or bromo, or X is methylene, Y is oxygen, R1 and R3 are both hydrogen, and R2 is hydrogen, fluoro, chloro or bromo; and R4 is hydrogen or C1-4 alkyl, or a salt thereof, have analgesic and/or anti-inflammatory activity.
