899795-65-4Relevant academic research and scientific papers
MAXI-K POTASSIUM CHANNEL OPENERS FOR THE TREATMENT OF FRAGILE X ASSOCIATED DISORDERS
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Page/Page column 85, (2021/11/26)
The present invention relates to the compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds provided herein can act as maxi-K potassium channel openers, which makes them suitable for use in therapy, particularly in the treatment or prevention of fragile X associated disorders, such as fragile X syndrome.
A Concise Synthesis of Potential COX Inhibitor BRL-37959 and Analogs Involving Bismuth(III) Catalyzed Friedel?Crafts Acylation
Ahmed, Shamsul Arefin,Hinz, Damon J.,Jellen, Marcus J.,Hossain, M. Mahmun
, (2018/11/30)
We report the development of a concise method of synthesizing possible cyclooxygenase (COX) inhibitor BRL-37959, which is believed to be a potent nonsteroidal anti-inflammatory drug (NSAID). The four-step synthesis greatly increased the efficiency of compound production from commercially available salicylaldehydes. The synthesis involved an optimized, bismuth(III) trifluoromethanesulfonate catalyzed benzoylation of a benzofuran ring.
NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
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Paragraph 0788-0789, (2018/11/26)
The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
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Page/Page column 97, (2014/08/06)
The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
Dynamic kinetic resolution of 2,3-dihydrobenzo[be]furans: Chemoenzymatic synthesis of analgesic agent BRL 37959
Bongen, Patrick,Pietruszka, J?rg,Simon, Robert Christian
, p. 11063 - 11070 (2012/10/07)
An efficient asymmetric synthesis of (S)-2,3-dihydrobenzo[be]furan-3- carboxylic acid (8 ) and (S)-5-chloro-2,3-dihydrobenzo[be]furan-3-carboxylic acid (8a b) was established. Key to the success was the highly stereoselective enzymatic kinetic resolution
Palladium-catalyzed oxidative cyclization of 3-phenoxyacrylates: An approach to construct substituted benzofurans from phenols
Li, Chengliang,Zhang, Yicheng,Li, Pinhua,Wang, Lei
, p. 4692 - 4696 (2011/07/08)
In this paper, a novel and applicable synthesis of benzofurans from commercially available phenols and propiolate through the direct oxidative cyclization has been developed. In the presence of Pd(OAc)2/PPh 3 and CF3COsub
A convenient method of synthesizing 3-ethoxycarbonylbenzofurans from salicylaldehydes and ethyl diazoacetate
Dudley, Matthew E.,Morshed, M. Monzur,Hossain, M. Mahmun
, p. 1711 - 1714 (2007/10/03)
We have developed a convenient one-pot procedure for the synthesis of 3-ethoxycarbonylbenzofurans from commercially available salicylaldehydes and ethyl diazoacetate. The method is high-yielding, efficient, simple and selective. Georg Thieme Verlag Stuttg
