93669-90-0Relevant academic research and scientific papers
A Concise Synthesis of Potential COX Inhibitor BRL-37959 and Analogs Involving Bismuth(III) Catalyzed Friedel?Crafts Acylation
Ahmed, Shamsul Arefin,Hinz, Damon J.,Jellen, Marcus J.,Hossain, M. Mahmun
, (2018/11/30)
We report the development of a concise method of synthesizing possible cyclooxygenase (COX) inhibitor BRL-37959, which is believed to be a potent nonsteroidal anti-inflammatory drug (NSAID). The four-step synthesis greatly increased the efficiency of compound production from commercially available salicylaldehydes. The synthesis involved an optimized, bismuth(III) trifluoromethanesulfonate catalyzed benzoylation of a benzofuran ring.
7-Aroyl-2,3-dihydrobenzofuran-3-carboxylic Acids and 7-Benzoyl-2,3-dihydrobenzothiophene-3-carboxylic Acids as Analgesic Agents
Boyle, Elizabeth A.,Mangan, Frank R.,Markwell, Roger E.,Smith, Stephen A.,Thomson, Michael J.,et al.
, p. 894 - 898 (2007/10/02)
The synthesis of a series of 7-aroyl-2,3-dihydrobenzofuran-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzothiophene-3-carboxylic acids is described.The isomeric 4-benzoyl-1,3-dihydrobenzofuran-1-carboxylic acid was also prepared.Compounds were
