936711-99-8

Upstream product

• 100-39-0 benzyl bromide 
• 494773-45-4 4-bromo-3-hydroxy-phenyl 4-methyl-benzenesulfonate 
• 6626-15-9 4-Bromoresorcinol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1379680-45-1 2,2'-bis(benzyloxy)-4,4'-dimethoxybiphenyl 
• 156206-33-6 2,2'-dihydroxy-4,4'-dimethoxybiphenyl 
• 1379680-47-3 C₃₈H₃₂O₄P₂ 
• 1379680-48-4 C₃₈H₃₂O₂P₂ 
• 70120-18-2 3-(benzyloxy)-4-bromophenol 
• 183474-19-3 4-methoxy-2-benzyloxybenzeneboronic acid 
• 150356-67-5 1-bromo-4-methoxy-2-(phenylmethoxy)benzene 

Relevant academic research and scientific papers

Helical Nano-crystallite (HNC) Phases: Chirality Synchronization of Achiral Bent-Core Mesogens in a New Type of Dark Conglomerates

Spontaneous generation of macroscopic homochirality in soft matter systems by self-assembly of exclusively achiral molecules under achiral conditions is a challenging task with relevance for fundamental scientific research and technological applications.

Stable axial chirality in metal complexes bearing 4,4′-substituted BIPHEPs: Application to catalytic asymmetric carbon-carbon bond-forming reactions

Not only electronic but also steric effects of 4,4′-substituents in BIPHEP derivatives and metal (Pd, Pt, and Au) complexes are shown to influence the stability of the biphenyl single bond rotation. While electron-donating or sterically demanding substituents on the 4,4′-positions destabilize the axial chirality of BIPHEP derivatives, electron-withdrawing or sterically less demanding ones on the 4,4′-positions stabilize the axis chirality. Particularly, the axial chirality of palladium dichloride complexes bearing BIPHEP with t-Bu and CF3 substituents on the 4,4′-positions is most labile and stable, respectively (ΔG≠ = 29.22 and 30.49 kcal mol-1 at 300 K; t1/2 = 7 and 56 years at 300 K). These enantiopure dicationic BIPHEPPd complexes can be employed for catalytic enantioselective arylation, alkenylation, and ene reactions to give the corresponding products in good-to-excellent yields and enantioselectivities. Significantly, in the carbonyl-ene reaction of trifluoropyruvate with isobutene, the turnover frequency (TOF) reached 58200 h-1. The remarkable effects of 4,4′-substituents in BIPHEP derivatives can be employed as a guiding principle in the design of versatile and efficient ligands.

TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS

The present invention relates to tetracyclic indole derivatives of formula (I); wherein Ar, D1, D2, D3, D4, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical composi