936752-28-2Relevant academic research and scientific papers
Method for synthesizing alkenyl phosphate compounds
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Paragraph 0112-0115, (2019/11/21)
The invention discloses a method for synthesizing alkenyl phosphate compounds with high selectivity. The method includes dissolving a gold catalyst, an alkyne shown as a formula II, and a phosphoric acid compound shown as a formula III into an organic solvent in a nitrogen atmosphere, stirring and reacting the mixture at 25-75 DEG C in a Schlenk reaction tube for 3-10 h, and subjecting an obtainedreaction solution to after-treatment to obtain an alkenyl phosphate compound shown as a formula Iv. The mole ratio of the gold catalyst, the alkyne shown as the formula II, and the phosphoric acid compound shown as the formula III is 0.01-0.05:1-2:1. In the method, the dual-function gold catalyst replaces present expensive ruthenium catalysts or high-toxicity mercury catalysts so that the methodhas advantages of high reaction stereoselectivity, low catalyst toxicity, low catalyst dosage, mild reaction condition, reduced energy consumption, a high yield, high substrate universality, simple and convenient operation, and the like.
Asymmetric hydrogenation of enol phosphinates by iridium catalysts having N,P ligands
Cheruku, Pradeep,Gohil, Suresh,Andersson, Pher G.
, p. 1659 - 1661 (2008/02/02)
Enol phosphinates, which are structural analogues of enol acetates, have for the first time been employed as substrates for Ir-catalyzed asymmetric hydrogenation. A number of enol phosphinates have been synthesized and reduced successfully with up to and above 99% ee.
