52193-85-8

Basic information

• Product Name: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL
• Synonyms: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL;R(+)-1-(2-NAPHTHYL)ETHANOL;(r)-(+)-α-methyl-2-naphthalenemethanol;(R)-(+)-2-(1-Hydroxyethyl)naphthalene;(1R)-1-(2-Naphthyl)ethanol;(R)-α-Methylnaphthalene-2-methanol;(αR)-α-Methylnaphthalene-2-methanol;(R)-(+)-alpha-Methyl-2-naphthalenemethanol (R)-(+)-2-(1-Hydroxyethyl)naphthalene
• CAS NO: 52193-85-8
• Molecular Formula: C₁₂H₁₂O
• Molecular Weight: 172.22
• Product Categories: Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry
• Mol File: 52193-85-8.mol
• Article Data: 332

Chemical Properties

• Melting Point: 68-70 °C(lit.)
• Boiling Point: 316°Cat760mmHg
• Flash Point: 145.4°C
• Appearance: /
• Density: 1.113
• Vapor Pressure: 0.000177mmHg at 25°C
• Refractive Index: 40 ° (C=1, MeOH)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol,Toluene
• BRN: 3195952
• CAS DataBase Reference: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL(52193-85-8)
• EPA Substance Registry System: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL(52193-85-8)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 52193-85-8(Hazardous Substances Data)

Usage

Uses

(R)-(+)-1-(2-Naphthyl)ethanol may be used to synthesize (S)-2-chloro-1-phenylethanol by reacting with 2-chloroacetophenone in the presence of a chiral bidentate titanium Lewis acid catalyst.

Application

(R)-(+)-1-(2-Naphthyl)ethanol is a useful research chemical.

InChI:InChI=1/C12H12O/c1-9(13)11-7-6-10-4-2-3-5-12(10)8-11/h2-9,13H,1H3/t9-/m1/s1

Upstream product

• 7228-47-9 2-(2-naphthyl)ethanol 
• 85880-67-7 1-(2-naphthyl)ethyl acetate 
• 247210-87-3 (1-naphthalen-2-yl-ethoxy)-diphenyl-silane 
• 827-54-3 2-naphthylethylene 
• 464-78-8 (1S)-(+)-ketopinic acid 
• 123-62-6 propionic acid anhydride 
• 18006-13-8 methyltriisopropoxytitanium(IV) 
• 66-99-9 β-naphthaldehyde 
• 97-72-3 2-Methylpropionic anhydride 
• 939-27-5 2-ethylnaphthalene 
• 100518-70-5 1-(2-naphthyl)-ethane-1-hydroperoxide 
• 75-24-1 trimethylaluminum 
• 32860-25-6 (R)-1-(2-naphtyl)ethyl acetate 
• 108-05-4 vinyl acetate 

Downstream Products

• 3082-62-0 (1S)-1-(2-naphthyl)ethylamine 
• 1159252-69-3 (3S)-(R)-1-(naphthalen-2-yl)ethyl 1-methyl-2-oxo-3-phenylpyrrolidine-3-carboxylate 
• 1159252-70-6 (3R)-(R)-1-(naphthalen-2-yl)ethyl 1-methyl-2-oxo-3-phenylpyrrolidine-3-carboxylate 
• 175288-51-4 (R)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-propionic acid methyl ester 
• 175288-52-5 (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-propionic acid methyl ester 
• 175288-53-6 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-methyl-1-naphthalen-2-yl-propyl ester 
• 175288-54-7 (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester 
• 93-08-3 methyl 2-naphthyl ketone 
• 7228-47-9 2-(2-naphthyl)ethanol 
• 175288-44-5 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-naphthalen-2-yl-ethyl ester 
• 130814-87-8 (S)-6-Methyl-5-((R)-1-naphthalen-2-yl-ethoxy)-2-phenyl-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione 
• 130814-88-9 (S)-4-Methyl-3-((R)-1-naphthalen-2-yl-ethoxy)-cyclohex-4-ene-1,1,2,2-tetracarbonitrile 

Relevant articles and documents

Ruthenium-catalyzed stereospecific benzylic alkylation of optically active benzyl esters with malonate nucleophiles

The transition metal-catalyzed stereospecific benzylic alkylation of optically active benzyl esters with active methylene compounds remains extremely rare. Herein, we describe the study for the ruthenium-catalyzed benzylic alkylation of chiral benzyl este

Nickel-Mediated Enantiospecific Silylation via Benzylic C-OMe Bond Cleavage

Benzylic stereocenters are found in bioactive and drug molecules, as enantiopure benzylic alcohols have been used to build such a stereogenic center, but are limited to the construction of a C-C bond. Silylation of alkyl alcohols has the potential to build bioactive molecules and building blocks; however, the development of such a process is challenging and unknown. Herein, we describe an unprecedented AgF-assisted nickel catalysis in the enantiospecific silylation of benzylic ethers.

Pickering-Droplet-Derived MOF Microreactors for Continuous-Flow Biocatalysis with Size Selectivity

Enzymatic microarchitectures with spatially controlled reactivity, engineered molecular sieving ability, favorable interior environment, and industrial productivity show great potential in synthetic protocellular systems and practical biotechnology, but their construction remains a significant challenge. Here, we proposed a Pickering emulsion interface-directed synthesis method to fabricate such a microreactor, in which a robust and defect-free MOF layer was grown around silica emulsifier stabilized droplet surfaces. The compartmentalized interior droplets can provide a biomimetic microenvironment to host free enzymes, while the outer MOF layer secludes active species from the surroundings and endows the microreactor with size-selective permeability. Impressively, the thus-designed enzymatic microreactor exhibited excellent size selectivity and long-term stability, as demonstrated by a 1000 h continuous-flow reaction, while affording completely equal enantioselectivities to the free enzyme counterpart. Moreover, the catalytic efficiency of such enzymatic microreactors was conveniently regulated through engineering of the type or thickness of the outer MOF layer or interior environments for the enzymes, highlighting their superior customized specialties. This study provides new opportunities in designing MOF-based artificial cellular microreactors for practical applications.