936833-87-3Relevant academic research and scientific papers
Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives
Suzuki, Shinya,Sugawara, Yuji,Tsuji, Riichiro,Tanimura, Ryuji,Kaneko, Chihiro,Yuzawa, Natsumi,Yagi, Mai,Kawai, Koji
, p. 3920 - 3924 (2017)
κ-Opioid receptor agonists with high selectivity over the μ-opioid receptor are attractive targets in the development of drugs for pain and pruritus. We previously reported the synthesis of 10α-hydroxy TRK-820 (1). In this study, we elucidated the biologi
MORPHINAN DERIVATIVE AND A PHARMACEUTICAL USE THEREOF
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, (2018/05/05)
PROBLEM TO BE SOLVED: To provide a compound having peripheral, selective opioid κ receptor agonistic action. SOLUTION: The present invention provides a morphinan derivative represented by the following formula (I) or formula (II), or a pharmacologically a
THERAPEUTIC OR PROPHYLACTIC AGENT FOR FUNCTIONAL BOWEL DISORDER
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Page/Page column 26, (2008/12/07)
A therapeutic or prophylactic agent for functional bowel disorders comprising as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic group or a pharmaceutically acceptable acid addition salt thereof is disclosed. The therapeutic or prophylactic agent for functional bowel disorders comprises as an effective ingredient a morphinan derivative or a pharmaceutically acceptable acid addition salt thereof, having a specific structure, such as N-(17-cyclopeopylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-3,4,5,6-tetrahydrophthalimide tartaric acid salt (Compound 10).
