936841-69-9

Usage

Uses

Used in Organic Synthesis:
4-Trifluoromethyl-pyridine-2-carbonitrile is used as a building block for the creation of various complex organic molecules. Its ability to participate in a range of chemical reactions makes it an essential component in the synthesis of diverse organic compounds.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 4-Trifluoromethyl-pyridine-2-carbonitrile is utilized as a key intermediate in the development of new drugs. Its derivatives have potential applications due to the compound's unique properties, which can contribute to the discovery of novel therapeutic agents.
Used in Research and Development:
4-Trifluoromethyl-pyridine-2-carbonitrile may also be employed in specific research and industrial applications where its distinct characteristics are advantageous. This includes exploring its properties for use in new technologies or processes that require such a versatile chemical intermediate.

Upstream product

• 3796-24-5 4-trifluoromethylpyridine 
• 7677-24-9 trimethylsilyl cyanide 
• 22253-59-4 1-oxido-4-(trifluoromethyl)pyridin-1-ium 

Downstream Products

• 588702-62-9 4-(trifluoromethyl)-2-pyridinecarboxylic acid 
• 640296-12-4 4-(trifluoromethyl)pyridine-2-carbonyl chloride 
• 872577-05-4 (4-(trifluoromethyl)pyridin-2-yl)methanamine 
• 2126903-00-0 (3aR,8aS)-2-(4-(trifluoromethyl)pyridin-2-yl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole 
• 939426-21-8 1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenyl-1-(4-(trifluoromethyl)pyridin-2-yl)ethanamine 
• 1339045-68-9 2-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)-4-(trifluoromethyl)pyridine 

Relevant academic research and scientific papers

C?H Cyanation of 6-Ring N-Containing Heteroaromatics

Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chemistry and the biomedical sciences. Herein, we report an approach to heteroaromatic C?H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures.

AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein "R1", "RA-1", "R2", "R3", and "Het" are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

FUSED TRICYCLIC AMIDE COMPOUNDS AS MULTIPLE KINASE INHIBITORS

Provided are fused tricyclic amide compounds, pharmaceutical compositions comprising at least one such fused tricyclic compound, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain tricyclic amide compounds that can be useful for inhibiting multiple (specifically BRAF and/or EGFR-T790M) kinases and for treating disorders mediated thereby.

PYRIDINE COMPOUND, PESTICIDAL COMPOSITION AND METHOD OF CONTROLLING PEST

A pyridine compound represented by the following general formula (1); the pyridine compound in which R1 is a C1-C3 fluoroalkyl group or a C1-C3 fluoroalkoxy group; the pyridine compound in which R2 is a hydrogen atom; the pyridine compound in which R2 is a group represented by Q1; a pesticidal composition containing the pyridine compound as an active ingredient; and a method of controlling a pest including applying an effective amount of the pyridine compound to the pest or a place where the pest inhabits, are provided.